J Genet Med.  2009 Jun;6(1):62-66.

A Cytogenetic Analysis of Abortus with Spontaneous Abortion

Affiliations
  • 1Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea. gcenter@snu.ac.kr
  • 2Division of Research and Development, GenDix, Inc., Seoul, Korea.
  • 3Department of Clinical Pathology, Daejeon Health Sciences College, Deajeon, Korea.

Abstract

PURPOSE
Chromosomal abnormalities of abortuses have been used to investigate common etiologies of spontaneous abortion, but the frequencies and types of spontaneous abortions have demonstrated considerable variation among different countries and races.
MATERIALS AND METHODS
A cytogenetic analysis of 75 abortuses was performed at GenDix, Inc. from January 2006 to December 2007.
RESULTS
The frequency of chromosome abnormalities in abortuses was 32.0% (24/75 cases). Among the chromosomal abnormalities, trisomy was present in 62.5% (15/24 cases) of cases and the most frequent trisomy was trisomy 21 with an occurrence rate of 26.6% (4/15 cases). The following was trisomy 22 (3/15 cases) and trisomy 20 (2/15 cases). The average maternal age for abnormal karyotypes was 34.3+/-3.3.
CONCLUSION
Cytogenetic analysis of abortus is important for diagnosis and genetic counseling of patients with spontaneous abortion.

Keyword

Chromosome; Abortus; Karyotype
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