- Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test
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Shin HC, Lee HB, Yoo TK, Lee ES, Kim RN, Park B, Yoon KA, Park C, Lee ES, Moon HG, Noh DY, Kong SY, Han W
- KMID: 2504452
- Cancer Res Treat.
- 2020 Jul;52(3):697-713.
- doi: 10.4143/crt.2019.559
Purpose Hereditary cancer syndrome means that inherited genetic mutations can increase a person's risk of developing cancer. We assessed the frequency of germline mutations using an nextgeneration sequencing (NGS)–based multiple-gene panel... -
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- Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
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Yoon KA, Woo SM, Kim YH, Kong SY, Lee MK, Han SS, Kim TH, Lee WJ, Park SJ
- KMID: 2464315
- Gut Liver.
- 2019 Nov;13(6):683-689.
- doi: 10.5009/gnl18355
BACKGROUND/AIMS: Pancreatic ductal adenocarcinoma (PDA) is associated with an extremely poor prognosis. This study assessed the genetic diversity among patients with PDA and compared their mutational profiles before and after... -
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- Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
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Yoon KA, Woo SM, Kim YH, Kong SY, Han SS, Park SJ, Lee WJ
- KMID: 2439225
- Genomics Inform.
- 2018 Dec;16(4):e35.
- doi: 10.5808/GI.2018.16.4.e35
Biliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic... -
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- Status of BRCA1/2 Genetic Testing Practices in Korea (2014)
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Lee K, Jang JH, Lee ST, Yoon KA, Lee ES, Kim JW, Kong SY
- KMID: 2414132
- Lab Med Online.
- 2018 Jul;8(3):107-113.
- doi: 10.3343/lmo.2018.8.3.107
BACKGROUND: The aim of this study was to investigate the status of BRCA1/2 genetic testing practices in Korea in 2014. METHODS: A structured questionnaire was provided to the specialist in charge... -
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- Induction Chemotherapy with Gemcitabine and Cisplatin Followed by Simultaneous Integrated Boost–Intensity Modulated Radiotherapy with Concurrent Gemcitabine for Locally Advanced Unresectable Pancreatic Cancer: Results from a Feasibility Study
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Woo SM, Kim MK, Joo J, Yoon KA, Park B, Park SJ, Han SS, Lee JH, Hong EK, Kim YH, Moon H, Kong SY, Kim TH, Lee WJ
- KMID: 2394821
- Cancer Res Treat.
- 2017 Oct;49(4):1022-1032.
- doi: 10.4143/crt.2016.495
PURPOSE: This study assessed the feasibility and compliance of induction chemotherapy with gemcitabine and cisplatin followed by simultaneous integrated boost–intensity modulated radiotherapy (SIB-IMRT) with concurrent gemcitabine in patients with locally... -
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- A Novel Germline Mutation in BRCA1 Causes Exon 20 Skipping in a Korean Family with a History of Breast Cancer
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Yoon KA, Kong SY, Lee EJ, Cho JN, Chang S, Lee ES
- KMID: 2438999
- J Breast Cancer.
- 2017 Sep;20(3):310-313.
- doi: 10.4048/jbc.2017.20.3.310
Germline mutations in the BRCA1 and BRCA2 genes are strong genetic factors for predispositions to breast, ovarian, and other related cancers. This report describes a family with a history of... -
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- Chromothripsis in Treatment Resistance in Multiple Myeloma
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Lee KJ, Lee KH, Yoon KA, Sohn JY, Lee E, Lee H, Eom HS, Kong SY
- KMID: 2394765
- Genomics Inform.
- 2017 Sep;15(3):87-97.
- doi: 10.5808/GI.2017.15.3.87
Multiple myeloma (MM) is a malignant disease caused by an abnormal proliferation of plasma cells, of which the prognostic factors include chromosomal abnormality, β-2 microglobulin, and albumin. Recently, the term... -
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- Clinically Significant Unclassified Variants in BRCA1 and BRCA2 genes among Korean Breast Cancer Patients
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Yoon KA, Park B, Lee BI, Yang MJ, Kong SY, Lee ES
- KMID: 2388308
- Cancer Res Treat.
- 2017 Jul;49(3):627-634.
- doi: 10.4143/crt.2016.292
PURPOSE: Unclassified variants (UVs) of BRCA1 and BRCA2 genes are not defined as pathogenic for breast cancer, and their clinical significance currently remains undefined. Therefore, this study was conducted to... -
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- The Effectiveness of Ferritin as a Contrast Agent for Cell Tracking MRI in Mouse Cancer Models
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Lee CW, Choi SI, Lee SJ, Oh YT, Park G, Park NY, Yoon KA, Kim S, Kim D, Kim YH, Suh JS
- KMID: 2374188
- Yonsei Med J.
- 2017 Jan;58(1):51-58.
- doi: 10.3349/ymj.2017.58.1.51
PURPOSE: We aimed to investigate the effectiveness of ferritin as a contrast agent and a potential reporter gene for tracking tumor cells or macrophages in mouse cancer models. MATERIALS AND METHODS:... -
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- Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP
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Kim MK, Yoon KA, Park EY, Joo J, Lee EY, Eom HS, Kong SY
- KMID: 2366437
- Genomics Inform.
- 2016 Dec;14(4):205-210.
- doi: 10.5808/GI.2016.14.4.205
Interleukin-10 (IL10) plays an important role in initiating and maintaining an appropriate immune response to non-Hodgkin lymphoma (NHL). Previous studies have revealed that the transcription of IL10 mRNA and its... -
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- Nucleotide Excision Repair Gene ERCC2 and ERCC5 Variants Increase Risk of Uterine Cervical Cancer
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Joo J, Yoon KA, Hayashi T, Kong SY, Shin HJ, Park B, Kim YM, Hwang SH, Kim J, Shin A, Kim JY
- KMID: 2454349
- Cancer Res Treat.
- 2016 Apr;48(2):708-714.
- doi: 10.4143/crt.2015.098
PURPOSE: Defects in the DNA damage repair process can cause genomic instability and play an important role in cervical carcinogenesis. The purpose of this study was to analyze the association... -
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- Infrared spectroscopy characterization of normal and lung cancer cells originated from epithelium
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Lee SY, Yoon KA, Jang SH, Ganbold EO, Uuriintuya D, Shin SM, Ryu PD, Joo SW
- KMID: 1726901
- J Vet Sci.
- 2009 Dec;10(4):299-304.
- doi: 10.4142/jvs.2009.10.4.299
The vibrational spectral differences of normal and lung cancer cells were studied for the development of effective cancer cell screening by means of attenuated total reflection infrared spectroscopy. The phosphate... -
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- A Cytogenetic Analysis of Abortus with Spontaneous Abortion
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Hwang SM, Kwon KH, Yoon KA, Oh SK
- KMID: 2244892
- J Genet Med.
- 2009 Jun;6(1):62-66.
PURPOSE: Chromosomal abnormalities of abortuses have been used to investigate common etiologies of spontaneous abortion, but the frequencies and types of spontaneous abortions have demonstrated considerable variation among different countries... -
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- Transcriptional Regulation of the Estrogen Receptor alpha Gene by Testosterone in Cultures of Primary Rat Sertoli Cells
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Yang SK, Yoon KA, Yun EJ, Song KS, Kim JS, Kim YR, Park JI, Park SK, Hwang BD, Lim K
- KMID: 1511949
- J Korean Soc Endocrinol.
- 2006 Apr;21(2):106-115.
- doi: 10.3803/jkes.2006.21.2.106
BACKGROUND: We wanted to identify the presence of the estrogen receptor (ER) alpha in Sertoli cells and gain insight on the regulation of the ER alpha gene expression by testosterone... -
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- Transcriptional REpression of Vimentin Gene During All-TTrans Retinoic Acid-Induced Differentiation of HL-60 Cells
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Lim K, Kwon DW, Kim SM, Yoon KA, Son MY, Lee MS, Park JI, Yoon WH, Hwang BD
- KMID: 1944218
- J Korean Soc Endocrinol.
- 1998 Dec;13(4):601-611.
BACKGROUND: Vimentin is the major intermediate-size filament in the cytoplasm of cells from mesenchymal origin. The HL-60 cell is a unique human leukemic cell line capable of terminal differentiation with... -
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- The Compliance of the Patients advised Additional Laboratory Test or Treatment in the Periodic Health Screening
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Yoon KA, Kang JY, Cho JJ
- KMID: 2295445
- J Korean Acad Fam Med.
- 1998 Mar;19(3):292-300.
BACKGROUND: Recent increase in use of the periodic health screening is due to a concern for health. But study of patient's compliance with recommended periodic health screening has not yet... -
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- Correlation of Exercise-Induced Bronchoconstriction to PC20 and Maximal AirwayNarrowing on the Dose-Response Curve to Methacholine
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Lim HS, Yoon KA, Koh YY
- KMID: 2317896
- Tuberc Respir Dis.
- 1995 Apr;42(2):165-174.
BACKGROUND: Exercise is one of the most common precipitants of acute asthma encountered in clinical practice. The development of airflow limitation that occurs several minutes after vigorous exercise, i. g.... -
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- Comparative study on the activation status of neutrophils in exercise -and allergen- induced asthma
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Choi JH, Kim H, Kim HJ, Koh YY, Yoon KA
- KMID: 1662674
- Allergy.
- 1994 Dec;14(4):658-673.
Asthma is considered today to be an inflammatory disease. The chronic asthmatic disease characterized by a bronchial hyperreactivity is assumed to be the result of an ongoing inflam matory process.... -
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- Acute appendicitis as a complication of Henoch-Schonlein purpura
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Um YK, Oh SM, Oh KY, Yoon KA, Chi JG, Choi DH, Kim SC
- KMID: 1690787
- Pediatr Allergy Respir Dis.
- 1993 Dec;3(2):130-137.
No abstract available. -
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- Factors determining airway responses to allergen provocation tests in asthmatic children
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Lim HS, Kwon KB, Yoon KA, Koh YY, Kim DH
- KMID: 1693570
- Allergy.
- 1993 Sep;13(3):286-295.
No abstract available. -
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