Korean J Hepatobiliary Pancreat Surg.
1999 Aug;3(2):181-186.
A case of Small Cell Carcinoma of the Gallbladder
- Affiliations
-
- 1Department of General Surgery, National Medical Center, Seoul, Korea.
- 2Department of Patholgy, National Medical Center, Seoul, Korea.
Abstract
- Small cell carcinoma of the gallbladder is a rare neoplasm with a high malignant potential, representing about 4% of all carcinomas in this organ. It predominantly develops in older women with cholelithiasis and deaths usually occur within a few months after the diagnosis. We report a case with a small cell carcinoma of the gallbladder with literature review. A case of 74-year-old woman with fever and abdominal pain for days was temporarily diagnosed as empyema of the gallbladder and received emergency cholecystostomy. 15 days later, she underwent cholecystectomy. Pathological examination of the gallbladder revealed small cell carcinoma. Of the immunohistochemical stains for neuroendocrine and other tumor markers, this tumor was positive for cytokeratin, NSE, lysozyme, gastrin,p53 and p16 and negative for CEA, chromogranin, synaptophysin, somatostatin, serotonin and ACTH. The small cell was partially originated from the common premobial cell with bidirectional differentiation. She died of cancer cachexia 2 months after initial operation.
Keyword
MeSH Terms
-
Abdominal Pain
Adrenocorticotropic Hormone
Aged
Cachexia
Carcinoma, Small Cell*
Cholecystectomy
Cholecystostomy
Cholelithiasis
Coloring Agents
Diagnosis
Emergencies
Empyema
Female
Fever
Gallbladder*
Humans
Keratins
Muramidase
Neuroendocrine Tumors
Serotonin
Somatostatin
Synaptophysin
Biomarkers, Tumor
Adrenocorticotropic Hormone
Coloring Agents
Keratins
Muramidase
Serotonin
Somatostatin
Synaptophysin
