Korean J Gastrointest Endosc.  2004 Jun;28(6):307-311.

A Case of Small Cell Carcinoma in the Stomach

Affiliations
  • 1Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk, Korea. psm@med.chungbuk.ac.kr
  • 2Department of Pathology, Chungbuk National University College of Medicine, Chungbuk, Korea.

Abstract

Small cell carcinoma (SmCC) of stomach is a very rare and aggressive malignancy with extremely poor prognosis. Most patients with gastric SmCC die within 1 year of diagnosis. A standard treatment for gastric SmCC has not been established, but surgical excision and/or combination chemotherapy should be considered to promote long term survival. We report a case of small cell carcinoma of stomach in a 66-year-old woman with dysphagia. A gastroscopic examination revealed a polypoid mass with ulceration on the lesser curvature of the gastric body extending to the gastro-esophageal junction. An endoscopic biopsy showed a solid proliferation of small, monotonous tumor cells with hyperchromatic nuclei and scanty cytoplasm. Immunohistochemically, the neoplastic cells were positive for chromogranin, synaptophysin and NSE, and negative for CD45. No tumor was detected on examination of the chest. Therefore, primary SmCC was diagnosed preoperatively.

Keyword

Dysphagia; Gastric small cell carcinoma

MeSH Terms

Aged
Biopsy
Carcinoma, Small Cell*
Cytoplasm
Deglutition Disorders
Diagnosis
Drug Therapy, Combination
Female
Humans
Prognosis
Stomach*
Synaptophysin
Thorax
Ulcer
Synaptophysin
Full Text Links
  • KJGE
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr