Korean J Gastrointest Endosc.
2007 Jun;34(6):339-342.
Tuberculous Meningitis in a Patient with Crohn's Disease, Which was Treated with Infliximab
- Affiliations
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- 1Department of Gastroenterology, Korea University Medical Center Guro Hospital, Seoul, Korea. gi7pjj@yahoo.co.kr
- 2Infectious Department, Korea University Medical Center Guro Hospital, Seoul, Korea.
Abstract
- Clinical trials of tumor necrosis factor (TNF) inhibitor have demonstrated significant efficacy in those patients with Crohn's disease that is not responsive to other anti-inflammatory drug. Infliximab is a human-murine chimeric monoclonal antibody with a high binding affinity and specificity for TNF-alpha. Yet therapy with infliximab is associated with an increased risk of opportunistic infection, and especially tuberculosis. Here we reported on a case of tuberculous meningitis in 26-year-old man, and he was treated with infliximab for uncontrolled and fistulous Crohn's disease. We also include a review of the literature.
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