Korean J Gastrointest Endosc.  2010 Jul;41(1):5-9.

Recent Eradication Rates of First-line Triple Regimens for H. pylori Infection

Affiliations
  • 1Department of Internal Medicine, Dongguk University-Seoul, Graduate School of Medicine, Goyang, Korea. limyj@duih.org
  • 2Department of Family Medicine, Dongguk University-Seoul, Graduate School of Medicine, Goyang, Korea.

Abstract

BACKGROUND/AIMS
Decreasing trend of eradication rate of H. pylori using first-line triple regimens (proton pump inhibitor, amoxicillin, clarithromycin) has been issued. Longer therapies may become more popular if there are better results. Recent eradication rate should be examined and proper recommendation should be timely done according to the result.
METHODS
We examined recent eradication rates of first-line triple regimens and compared eradication rate according to the duration of this first-line therapy for H. pylori infection. The 976 patients received first-line triple therapy at the single center from November, 2005 to October, 2009 were retrospectively analyzed. Urea breath test was done at four to six weeks after completion of eradication therapy.
RESULTS
Overall eradication rate of triple regimen by intention to treat analysis was 80.4% (785/976). One week eradication rate has decreasing trend and below 73.3% during recent 2 years. Eradication rate in 2 weeks group (83.3%, 165/198) was significantly higher than 1 week group (73.3%, 198/270) from November, 2007 to October, 2009 (p<0.01).
CONCLUSIONS
Our results showed that 2 weeks triple regimen should be preferred as first-line therapy for H. pylori eradication.

Keyword

Helicobacter pylori; Eradication
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