A Case of Primary Low-grade Hepatic B-cell Lymphoma of Mucosa-associated Lymphoid Tissue ( MALT )-Type

Yang, Ung Suk; Cho, Mong; Song, Chul Soo; Lee, Suck Hong; Song, Geun Am; Park, Seung Keun; Oah, Hyung Myung; Kang, Yang Ho; Park, Sung Min; Lee, Sun Kyung; Kim, Dong Heon

Abstract

In this report, we describe the clinical, histological, and immunohistochemical features for a case of primary low-grade B-cell lymphoma of liver which was found incidentally. It was a round solitary nodule with a diameter of 3 cm. On abdominal CT, it appeared as a well defined hypodense and non enhanced mass in Coudinauds segment 6. The MRI showed low signal intensity in Tl-weighted imaging and high signal intensity in T2-weighted imaging. There was no evidence of the lymphoma in the extrahepatic regions. Right posterior segmentectomy of the liver was performed. The pathology showed the typical manifestation of a low-grade B-cell lymphoma of mucosa-associa.ted lymphoid tissue (MALT)-type. The centrocyte-like cells surrounded reactive B-cell follicles and formed lymphoepithelial lesions on bile ducts. The atypical lymphocytes were CD20 positive and ??-light chain positive. Primary hepatic lymphomas are rare but the lympomas of MALT can occur in numerous sites including stornach, intestine, salivary gland, lung, thyroid, ocular adnexa, thymus, urinary bladder, kidney, trachea, gallbladder and breast. The liver should be added to the list of extranodal sites where low-grade MALT lymphoma may occur. Primary low-grade hepatic B-cell lymphoma of mucosa-associated lymphoma tissue is required to be considered when a hepatic mass is found incidentally.