Korean J Anesthesiol.  1990 Jun;23(3):373-380. 10.4097/kjae.1990.23.3.373.

Clinical Experience of Pituitary Injectin of Phenol for Relief of Cancer Pain

Affiliations
  • 1Department of Anesthesiology, Chonnam Medical School, Kwang-ju, Korea.
  • 2Department of Pain Clinic, Chonnam Medical School, Kwang-ju, Korea.

Abstract

Moriccas technique, neuroadenolysis of the pituitary gland through direct injection of alcohol, was performed 5 times on three cancer patients at chonnam university hospital. Two of the three patients had complete pain relief. During this procedure there was no any severe complications except diabetes insipidus, but it was treated uneventfully with indomethacin and fluid administration. Although several theories including destructiorr of the thalamic and hypothalamic nerve pathway, pituitary hormone and endorphin on the mechanism of pain relief by the neuroadenolysis have been reported, it is still not clearly determined. This technique is considered to be an exceedingly useful method for management of intractable pain in inoperable cancer patients.

Keyword

Pituitary neuroadenolysis; Cancer pain; Neurolytic agent

MeSH Terms

Diabetes Insipidus
Endorphins
Humans
Indomethacin
Jeollanam-do
Pain, Intractable
Phenol*
Pituitary Gland
Endorphins
Indomethacin
Phenol
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