Korean J Anesthesiol.  1997 Jun;32(6):953-958. 10.4097/kjae.1997.32.6.953.

Effects of Autologous Platelet-Rich Plasma on Postoperative Blood Loss and Transfusion Requirements in Cardiac Surgery

• Hong YW
• Yoo ES
• Bang SO
• Kwak YL
• Song GH
• Lee CS
• Nam SB
• Kim MO

• KMID: 2237759
• DOI: http://doi.org/10.4097/kjae.1997.32.6.953

Abstract

BACKGROUND
Patients undergoing cardiac surgery employing cardiopulmonary bypass frequently require transfusion of homologous blood products and, therefore, are exposed to the risk of transfusions. A administration of autologous platelet-rich plasma may reduce homologous transfusion and attendant risks. This study was designed to investigate the effect of preoperative collection of platelet-rich plasma on the requirement of homologous transfusion and postoperative blood loss in patients undergoing open heart surgery.
METHODS
Twenty seven patients undergoing cardiac surgery were divided into control group(n=11) and autologous platelet-rich plasmaphereris(PRP) group(n=16). Autologous platelet-rich plasma was retransfused after offbypass. Hematocrit, platelet count, PT(prothrombin time), PTT(partial thromboplastin time), postoperative blood loss and transfusion requirement were measured.
RESULTS
There was no statistical significance between control and PRP group in homologous transfusion and postoperative blood loss. There was no difference in hemoatocrit, platelet count, PT or PTT on immediate post surgery or on day 1.
CONCLUSIONS
Autologous platelet-rich plasma did not reduce postoperative blood loss or transfusion reguirements in cardiac surgery.

Keyword

Transfusion; platelet-rich plasmapheresis; Surgery; cardiac

MeSH Terms

Cardiopulmonary Bypass
Hematocrit
Humans
Platelet Count
Platelet-Rich Plasma*
Postoperative Hemorrhage*
Thoracic Surgery*
Thromboplastin
Thromboplastin