Korean J Anesthesiol.  2012 Feb;62(2):148-153. 10.4097/kjae.2012.62.2.148.

Effects of ulinastatin treatment on myocardial and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. yschoi@yuhs.ac
  • 2Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Daegu, Korea.

Abstract

BACKGROUND
We determined the protective effects of a high dose of ulinastatin on myocardial and renal function in patients undergoing aortic valve replacement with cardiopulmonary bypass (CPB).
METHODS
Sixty patients were assigned randomly to either the ulinastatin group (n = 30) or the control group (n = 30). In the ulinastatin group, ulinastatin (300,000 U) was given after the induction of anesthesia, ulinastatin (400,000 U) was added to the CPB pump prime, and then ulinastatin (300,000 U) was administered after weaning from CPB. In the control group, the same volume of saline was administered at the same time points. Creatine kinase-MB levels were assessed 1 day before surgery, and on the first and second postoperative day (POD 1 and 2). Serum creatinine and cystatin C levels were assessed 1 day before surgery, upon intensive care unit arrival, and on POD 1 and 2. The level of plasma neutrophil gelatinase-associated lipocalin was assessed before induction of anesthesia, upon ICU arrival, and on POD 1.
RESULTS
No significant differences were observed in serum levels of creatine kinase-MB and biomarkers of renal injury between the two groups at any point during the study period.
CONCLUSIONS
Ulinastatin showed no cardiac or renal protective effects after CPB in patients undergoing aortic valve replacement.

Keyword

Cardiac surgical procedures; Cardiopulmonary bypass; Myocardiac protection

MeSH Terms

Anesthesia
Aortic Valve
Biomarkers
Cardiac Surgical Procedures
Cardiopulmonary Bypass
Creatine
Creatinine
Cystatin C
Glycoproteins
Humans
Intensive Care Units
Lipocalins
Neutrophils
Plasma
Weaning
Creatine
Creatinine
Cystatin C
Glycoproteins
Lipocalins
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