Int Neurourol J.  2011 Dec;15(4):222-227.

Continence Rate and Oncological Feasibility after Total Transurethral Resection of the Prostate as an Alternative Therapy for the Treatment of Prostate Cancer: A Pilot Study

• Jeong HJ
• Kwon DD

Abstract

PURPOSE
The value of total transurethral resection of prostate cancer (TURPC) as an alternative therapy was first recognized by Hans J. Reuter. Thus, we conducted the study of prospectively collected data to verify total TURPC as an alternative therapy forlocalized prostate cancer.
METHODS
From January 2008 to July 2011, 14 patients with a mean age of 76.1 years (range, 66 to 89 years) with clinically localized prostate cancer were treated by prostatic resection by the corresponding author with curative intention.
RESULTS
The mean duration of TURPC was 51.7 minutes (range, 30 to 120 minutes) and the mean amount of prostatic tissue resected was 21.2 g (range, 5 to 66 g). An intra- and/or postoperative blood transfusion was necessary in 2 cases. Hyponatremia was found in 7 patients. Six months after TURPC, 3 cases of grade 1 and 1 case of grade 2 incontinence were observed. Three patients in the high-risk group did not achieve a prostate specific antigen (PSA) nadir of < or =0.2 ng/mL. PSA recurrence occurred in one case in our series. Newly developed lymph node or distant metastases were not observed during the follow-up period.
CONCLUSIONS
According to our results, transurethral resection for prostate cancer can be performed with reasonable oncological results. The PSA nadir levels, and rates of biochemical failure and postoperative complications, including incontinence, were comparable with the published results for other procedures. TURPC is also inexpensive and non-invasive, and requires short hospitalization and a short surgical time without vesicourethral anastomosis.

Keyword

Urinary incontinence; Transurethral resection of prostate; Prostatic neoplasms; Prostate-specific antigen

MeSH Terms

Blood Transfusion
Follow-Up Studies
Hospitalization
Humans
Hyponatremia
Lymph Nodes
Neoplasm Metastasis
Operative Time
Pilot Projects
Postoperative Complications
Prospective Studies
Prostate
Prostate-Specific Antigen
Prostatic Neoplasms
Recurrence
Transurethral Resection of Prostate
Urinary Incontinence
Prostate-Specific Antigen