Korean Circ J.  1989 Jun;19(2):229-236. 10.4070/kcj.1989.19.2.229.

Thrombolysis by Recombinant Tissue-Type Plasminogen Activator in Patients with Acute Myocardial Infarction

• Kim DK
• Kim JJ
• Kim CH
• Do MH
• Park SW
• Sohn DW
• Ryu KH
• Oh BH
• Park YB
• Choi YS
• Seo JD
• Lee YW

• KMID: 2229408
• DOI: http://doi.org/10.4070/kcj.1989.19.2.229

Abstract

Myocardial infarction is usually associated with thrombotic occlusion of an artherosclerotic coronary artery. Reperfusion induced by administration of thrombolytic agents may presserve myocardial function and reduce mortality. At a mean of 272 minutes from symtom onset, 7 patients with acute myocardial infarction received recombinant tissue-type Plasminogen Activator. The results are as followings: 1) Reperfusion of the infarct-related artery was observed in all of the 5 patients in whom coronary angiography was performed 19 hour after initiation of drug infusion. Ergonovine challenge test, done in 1 patient who showed normal coronary artery, did not induced coronary spasm. 2) The maximal value of Creatine Kinase and Creatine Kinase-MB(2098+/-2107U/L and 728+/-532U/L, respectively) occured at 7.2+/-4.3 hour, respectively. A nadir value of fibrinogen(42+/-21% of the preinfusion value) occured at 3.1+/-2.0 hour. 3) Major bleeding episodes occured in 3 patients. Major cardiac events were angina followed by percutaneous transluminal coronary angioplasty in 1 patient; cardiogenic shock in 2 patients, one of whom also experienced recurrent ventricular tachycardia;reinfarction in 1 patient, 3 of the 7 patients died.

Keyword

Acute myocardial infarction; Thrombolysis; Recombinant tissue-type Plasminogen Acivator(rt-PA)

MeSH Terms

Angioplasty, Balloon, Coronary
Arteries
Coronary Angiography
Coronary Vessels
Creatine
Creatine Kinase
Ergonovine
Fibrinolytic Agents
Hemorrhage
Humans
Mortality
Myocardial Infarction*
Reperfusion
Shock, Cardiogenic
Spasm
Tissue Plasminogen Activator*
Creatine
Creatine Kinase
Ergonovine
Fibrinolytic Agents
Tissue Plasminogen Activator