Korean Circ J.  1998 Jun;28(6):1025-1030. 10.4070/kcj.1998.28.6.1025.

A Case of Transcatheter Alcohol Ablation of the Septum in a Patient of Hypertrophic Obstructive Cardiomyopathy

• Kim YJ
• Jung WH
• Choi SJ
• Choi KL
• Kim EA
• Lee JK
• Jin DK
• Dang Q
• Oh SJ
• Son MS
• Son JW
• Choi IS
• Shin EK

• KMID: 2228906
• DOI: http://doi.org/10.4070/kcj.1998.28.6.1025

Abstract

Hypertrophic obstructive cardiomyopathy (HOCM) is characterized by inappropriate myocardial hypertrophy that occurred in the absence of an obvious cause for the hypertrophy and dynamic left ventricular outflow tract obstruction, caused by asymmetrical septal hypertrophy and systolic anterior motion of the anterior mitral leaflet. The pathophysiological abnormality in HOCM is diastolic dysfunction, abnormal stiffness of the left ventricle with resultant impaired ventricular filling and impaired vasodilator reserve (perhaps related to the thickened and narrowed small intramural coronary arteries found in HOCM). During the early course of this progressive disease, treatment consists of negative inotropic drugs. Surgery has been the only therapeutic option in patients with hypertrophic cardiomyopathy who are resistant to drug treatment and sequential pacemaker therapy. We describe a novel catheter-based technique that may replace surgical myocardial reduction. The technique is interventional infarction of a portion of the interventricular septum by the infusion of alcohol into a selectively catheterized septal artery.

Keyword

Dynamic LVOT obstruction; Interventional infarction

MeSH Terms

Arteries
Cardiomyopathy, Hypertrophic*
Catheters
Coronary Vessels
Heart Ventricles
Humans
Hypertrophy
Infarction