Korean Circ J.  1998 Jun;28(6):923-930. 10.4070/kcj.1998.28.6.923.

Diagnostic Value of Dipyridamole Tc-99m Tetrofosmin SPECT for Detection of Coronary Artery Disease

• Kim CW
• Kim YJ
• Park JC
• Lee JP
• Lee YS
• Kim HY
• Kim JJ
• Seung KB
• Roh TH
• Chae JS
• Kim JH
• Hong SJ
• Choi KB
• Kang SW

• KMID: 2228892
• DOI: http://doi.org/10.4070/kcj.1998.28.6.923

Abstract

Background
and Objects: Tc-99m tetrofomsin is a recently developed myocardial perfusion agent. We examined the diagnostic accuracy of dipyridamole Tc-99m tetrofosmin SPECT. MATERIALS AND METHOD: 61 patients underwent one-day rest/dipyridamole Tc-99m tetrofosmin SPECT. 26 patients had history of myocardial infarction. Coronary angiography, performed within 1 week after SPECT study, revealed normal coronary arteries or insignificant coronary artery stenosis in 19 and 22 patients (when considering > or = 50% or > or = 70% reduction of luminal diameter as significant stenosis).
RESULTS
Number of male was 39 (63.9%) and mean age was 59 (range 32 - 84). The diagnostic accuracy of dipyridamole Tc-99m tetrofosmin SPECT for detection of coronary artery disease (> or = 50% and > or = 70% coronary artery stenosis, respectively) was as follows: sensitivity 90.5%, 90.0%, specificity 73.7%, 66.7%, positive predictive value 88.4%, 83.7%, negative predictive value 77.8%, 77.8% and predictive accuracy was 85.2%, 81.9% respectively. The overall sensitivity and specificity of dipyridamole Tc-99m tetrofosmin SPECT for detection of individual coronary stenosis (> or = 50% and > or = 70% coronary stenosis by coronary angiography) were 64.6%, 64.1% and 86.4%, 85.7% respectively. In patients without myocardial infarction, sensitivity 76.5%, specificity 76.5%, positive predictive value 83.3%, negative predictive value 76.5% and predictive accuracy was 80.0%.
CONCLUSION
One-day rest/stress dipyridamole Tc-99m tetrofosmin myocardial SPECT is a useful noninvasive method for detection of coronary artery disease.

Keyword

Dipyridamole Tc-99m tetrofosmin SPECT; Coronary artery disease

MeSH Terms

Coronary Angiography
Coronary Artery Disease*
Coronary Stenosis
Coronary Vessels*
Dipyridamole*
Humans
Male
Myocardial Infarction
Perfusion
Phenobarbital
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon*
Dipyridamole
Phenobarbital