J Stroke.  2014 May;16(2):91-96.

Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients

Affiliations
  • 1Department of Neurology, Kosin University College of Medicine, Busan, Korea. nekim@ns.kosinmed.or.kr

Abstract

BACKGROUND
AND PURPOSE: Stroke is common among cancer patients. However, risk factors and biomarkers of stroke in cancer patients are not well established. This study aimed to investigate risk factors and biomarkers as well as etiology of ischemic stroke in cancer patients.
METHODS
A retrospective review was conducted in cancer patients with ischemic stroke who were admitted to a general hospital in Busan, Korea, between January 2003 and December 2012. The risk factors and biomarkers for stroke and stroke subtypes in cancer patients were compared with age- and sex-matched noncancer patients with ischemic stroke who were admitted to the same hospital during the same period.
RESULTS
One hundred fifty-six cancer patients with ischemic stroke were identified. Cancer patients with ischemic stroke were found to have a significantly lower proportion of hypertension, atrial fibrillation, hyperlipidemia, and ischemic heart disease than noncancer patients with ischemic stroke. However, stroke biomarkers, such as erythrocyte sedimentation rate and high-sensitivity C-reactive protein, fibrinogen, pro-brain natriuretic peptide, and D-dimer levels, were significantly increased in cancer patients with ischemic stroke than in noncancer patients. Large-artery atherosclerosis and stroke of undetermined cause were more common in cancer patients with ischemic stroke than in noncancer patients with ischemic stroke.
CONCLUSIONS
Cancer patients with ischemic stroke showed different risk factors, stroke biomarkers, and stroke etiology compared with noncancer patients with ischemic stroke.

Keyword

Biomarker; Cancer; Ischemic stroke; Risk factor

MeSH Terms

Atherosclerosis
Atrial Fibrillation
Biomarkers*
Blood Sedimentation
Busan
C-Reactive Protein
Fibrinogen
Hospitals, General
Humans
Hyperlipidemias
Hypertension
Korea
Myocardial Ischemia
Retrospective Studies
Risk Factors*
Stroke*
C-Reactive Protein
Fibrinogen
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