Dement Neurocogn Disord.  2012 Sep;11(3):104-110. 10.12779/dnd.2012.11.3.104.

Behavioral and Psychological Symptoms in Patients with Parkinson's Disease According to Cognitive Function

Affiliations
  • 1Department of Neurology, Inha University School of Medicine, Incheon, Korea. seonghye@inha.ac.kr

Abstract

BACKGROUND
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor symptoms such as cognitive impairment and neuropsychiatric symptoms. The aim of this study was to investigate the spectrum of neuropsychiatric symptoms in PD according to cognitive function.
METHODS
One hundred twenty seven patients with PD were consecutively recruited. They had undergone an intensive interview with a neurologist and the Seoul Neuropsychological Screening Battery-dementia version, and were divided into three groups: 27 patients in PD with normal cognition (PDNC), 57 in PD with mild cognitive impairment (PDMCI), and 43 in PD with Dementia (PDD). Forty five healthy controls without memory complaints were also recruited. The caregivers of all participants administered the Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI).
RESULTS
There were significant differences in the CGA-NPI score (22.8+/-20.9 vs. 6.4+/-10.1 vs. 1.7+/-3.9 vs. 1.0+/-1.6, p<0.001), and the prevalence of neuropsychiatric symptoms (100% vs. 64.9% vs. 37.0% vs. 44.4%, p<0.001) among PDD, PDMCI, PDNC and control groups. Depression was the most common symptom (43.3%), followed by anxiety (31.5%), apathy (26.8%), and night-time behavior (26.8%) in all PD patients. Delusion, hallucination, and aberrant motor behavior were observed frequently in PDD, but were rare in PDMCI.
CONCLUSIONS
Depression was the most common neuropsychiatric symptom in PD. The presence of delusion, hallucination, or aberrant motor behavior may suggest PDD. The neuropsychiatric symptoms were not prevalent in PD with normal cognition.

Keyword

Parkinson's disease; Cognitive impairment; Neuropsychiatric symptoms

MeSH Terms

Anxiety
Apathy
Caregivers
Cognition
Delusions
Dementia
Depression
Hallucinations
Humans
Mass Screening
Memory
Mild Cognitive Impairment
Neurodegenerative Diseases
Parkinson Disease
Prevalence
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