J Korean Ophthalmol Soc.  2013 Nov;54(11):1788-1793. 10.3341/jkos.2013.54.11.1788.

Thrombocytopenia after Intravitreal Bevacizumab Injection for Macular Edema in Branch Retinal Vein Occlusion

Affiliations
  • 1Department of Ophthalmology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Ilsan, Korea. ophtha@naver.com

Abstract

PURPOSE
To report a rare case of thrombocytopenia after intravitreal bevacizumab injection (IVBI) in a patient with macular edema secondary to branch retinal vein occlusion (BRVO).
CASE SUMMARY
A 52-year-old female presented to our clinic with complaints of visual disturbance in her right eye for 2 months. She was receiving hemodialysis therapy 3 times a week for 4 years due to chronic renal failure. Unilateral macular edema secondary to BRVO was observed on fundus examination and was confirmed with optical coherence tomography (OCT). The first IVBI was performed, and an additional injection was given 4 weeks later. Four weeks after the second injection, thrombocytopenia was present. The patient was followed up in our clinic without IVBI for 8 weeks and the platelet count recovered. Thrombocytopenia was reconfirmed after 2 additional monthly injections. After she revisited our clinic without IVBI for 8 weeks, the platelet count recovered without any treatment.
CONCLUSIONS
When a patient presents with thrombocytopenia after IVBI with macular edema in BRVO, thrombocytopenia due to IVBI should be considered as a possible diagnosis.

Keyword

Branch retinal vein occlusion; Intravitreal bevacizumab; Macular edema; Thrombocytopenia

MeSH Terms

Antibodies, Monoclonal, Humanized
Diagnosis
Female
Humans
Kidney Failure, Chronic
Macular Edema*
Middle Aged
Platelet Count
Renal Dialysis
Retinal Vein Occlusion*
Retinal Vein*
Retinaldehyde*
Thrombocytopenia*
Tomography, Optical Coherence
Bevacizumab
Antibodies, Monoclonal, Humanized
Retinaldehyde
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