J Korean Ophthalmol Soc.  2012 Dec;53(12):1889-1892. 10.3341/jkos.2012.53.12.1889.

Treatment of Recurrent Conjunctival Papilloma with Topical Mitomycin C

• Hwang JH
• Shin KH
• Lee SK
• Song JS
• Kwon JW

• KMID: 2216407
• DOI: http://doi.org/10.3341/jkos.2012.53.12.1889

Abstract

PURPOSE
To provide a case report of 1 patient (1 eye) who experienced recurrences of conjunctival papilloma and was treated with complete resection, electrocauterization, cryotherapy, intraoperative application of mitomycin C and postoperative topical mitomycin C.
CASE SUMMARY
We evaluated the clinical course of a 42-year-old male with recurrent conjunctival papillomas on the left upper and lower tarsal conjunctiva who was treated 10 times with a simple resection over the past 8 years. The patient was treated with complete resection, electrocauterization, intraoperative application of mitomycin C and cryotherapy. Topical mitomycin C was applied for 1 month. There was no recurrence or complications for 12 months postoperatively.
CONCLUSIONS
Complete resection, electrocauterization, intraoperative application of mitomycin C, cryotherapy and topical mitomycin C in patients with recurrent conjunctival papilloma was shown to be an effective treatment without recurrence and complications.

Keyword

Cryotherapy; Mitomycin C; Recurrnet conjunctival papilloma

MeSH Terms

Adult
Conjunctiva
Cryotherapy
Humans
Male
Mitomycin
Papilloma
Recurrence
Mitomycin

Figure

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  Figure 1 Anterior segment photograph before (A, B) and after (C, D) surgery. Flat papillomas on the surface of the upper (A) and lower (B) tarsal conjunctiva before surgery. One year after surgery, there is no recurrence of the mass or complications (C, D).

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  Figure 2 Light microscopic view reveals multiple fibrovascular fronds (arrows) covered by non-keratinizing stratified squamous epithelium (arrowheads), characteristic pathologic features of papilloma. (H&E stain, ×100, scale line represents 50 micrometers).

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