J Korean Ophthalmol Soc.  2003 Aug;44(8):1924-1930.

Treatment of Conjunctival-Corneal Intraepithelial Neoplasia with Topical Mitomycin C

• Park HJ
• Lee JE
• Lee JS
• Park DY

Abstract

PURPOSE
To evaluate the therapeutic effect of topical mitomycin C (MMC) on the diffuse conjunctival-corneal intraepithelial neoplasia (CCIN). METHODS: Three patients histopathologically confirmed the conjunctival-corneal intraepithelial neoplasia (CCIN) received topical drop of 0.04% MMC four times daily for 2 to 4 weeks. Ocular complications and recurrence were evaluated under slit lamp biomicroscope. RESULTS: One case received topical drop of 0.04% MMC four times daily for 2 weeks and two cases of CCIN received for 4 weeks in the same manner. These lesions were completely regressed and did not recur under slit lamp biomicroscope during the follow-up of 18 months, 6 months, and 5 months, respectively. Other complications except superficial punctate keratitis and conjunctival injection did not develope and visual acuities have been improved. CONCLUSIONS: It appears that the application of topical MMC alone could be a primary effective treatment for diffuse conjunctival-corneal intraepithelial neoplasia (CCIN).

Keyword

Conjunctival-corneal intraepithelial neoplasia (CCIN); Topical mitomycin C

MeSH Terms

Follow-Up Studies
Humans
Keratitis
Mitomycin*
Recurrence
Visual Acuity
Mitomycin