J Korean Ophthalmol Soc.  2012 Jul;53(7):1023-1026. 10.3341/jkos.2012.53.7.1023.

A Case of Syringocystadenoma Papilliferum of the Eyelid

• Lee DS
• Kim N
• Park HJ
• Choung HK
• Khwarg SI

• KMID: 2215863
• DOI: http://doi.org/10.3341/jkos.2012.53.7.1023

Abstract

PURPOSE
To report a case of syringocystadenoma papilliferum that presented as an eyelid nodule.
CASE SUMMARY
A 37-year-old woman presented with a mass around the punctum in the right lower eyelid margin, which had developed several years earlier and was increasing in size. The mass was a light pinkish nodule consisting of a few smooth-surface papillary lobules. The pathologic findings of the specimen obtained from a shaving biopsy showed a papillary projection which was covered with epithelium and communication with duct-like structures showing glandular configuration in the deep portion of the lesion. EMA-positive cells were found at the invaginated epithelium, implying a glandular epithelial origin. GCDFP-15-positive cells were found in the deep portion of the lesion, implying apocrine differentiation. The findings were compatible with syringocystadenoma papilliferum.
CONCLUSIONS
Syringocystadenoma papilliferum should be considered as a differential diagnosis of a solitary eyelid tumor.

Keyword

Eyelid mass; Syringocystadenoma papilliferum

MeSH Terms

Adult
Biopsy
Diagnosis, Differential
Epithelium
Eyelids
Female
Humans
Light

Figure

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  Figure 1 (A, B) Pinkish nodule consisting of a few smooth-surface papillary lobules around the punctum in the right lower eyelid.

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  Figure 2 (A, B) Papillary projection which is covered with epithelium, is communicating with duct-like structures. (H&E, ×40). (C) EMA-positive cells are found at the superficially-located epithelium (arrowheads). Glandular configuration is also seen in the deep portions of the lesion (asterisk) (×400). (D) GCDFP-15-positive cells (black arrow) are found in the deep portions of the lesion, implying apocrine differentiation (×400).

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