J Korean Ophthalmol Soc.  2010 Apr;51(4):575-580. 10.3341/jkos.2010.51.4.575.

Comparison of Outcome of Trabeculectomy With Mitomycin C and Ahmed Valve Implantation for Uveitic Glaucoma

  • 1Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Korea. yhsohn@konyang.ac.kr


To assess and compare the clinical outcomes of primary trabeculectomy with mitomycin C and Ahmed valve implantation for secondary open-angle glaucoma following uveitis.
This study was conducted retrospectively on 30 eyes of 25 patients with open-angle glaucoma secondary to uveitis that had undergone trabeculectomy with mitomycin C and 33 eyes of 24 patients that had undergone Ahmed valve implantation. The clinical outcome indicators used in this study were intraocular pressure (IOP), number of anti-glaucoma agents, surgical success rate and occurrence of complications.
Mean IOP and surgical success rate in patients who had undergone trabeculectomy with mitomycin C after a 12 month postoperative period were 14.0+/-8.2 mmHg and 76.7%, respectively, while those of patients with Ahmed valve implantation were 13.2+/-7.7 mmHg and 81.8%. The data did not show clinical significance. There was greater risk of surgical failure in patients at a younger age and/or with diabetes mellitus in cases of having gone through trabeculectomy with mitomycin C.
Both trabeculectomy with mitomycon C and Ahmed valve implantation can be considered as primary surgical treatments for patients with open-angle glaucoma secondary to uveitis. However, trabeculectomy with mitomycin C should only be applied to a limited extent in patients that are young and/or have diabetes mellitus.


Ahmed valve implantation; Trabeculectomy with mitomycin C; Uveitic glaucoma

MeSH Terms

Diabetes Mellitus
Glaucoma, Open-Angle
Intraocular Pressure
Postoperative Period
Retrospective Studies


  • Figure 1. Kaplan-Meier survival curve showing the cumulative probability of success following trabeculectomy with mitomycin C and Ahmed valve implantation. These two curves are not significantly different (p=0.223, log rank test).

  • Figure 2. Comparison of intraocular pressure (IOP) of trabeculectomy with mitomycin C and Ahmed valve implantation according to each follow-up periods. IOP of Ahmed valve implantation was significantly lower than trabeculectomy with mitomycin C after post-op 1day and 1 week. But, IOP of trabeculectomy with mitomycin C was maintained more stably during follow-up periods.



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