J Korean Ophthalmol Soc.  2016 May;57(5):710-717. 10.3341/jkos.2016.57.5.710.

Effect of 0.05% Cyclosporine A on the Ocular Surface after Photorefractive Keratectomy

• Kim YI
• Koo SH
• Ha SW
• Lee GJ
• Lee KW
• Park YJ

• KMID: 2212712
• DOI: http://doi.org/10.3341/jkos.2016.57.5.710

Abstract

PURPOSE
To evaluate the effect of 0.05% cyclosporine A on the ocular surface after photorefractive keratectomy (PRK).
METHODS
This retrospective study included 50 patients who underwent PRK. Patients were divided into two groups: 25 patients in group I were treated with topical 0.05% cyclosporine A with conventional medication, and 25 patients in group II were treated with conventional medication. Visual acuity (VA), tear break-up time (BUT), fluorescein staining score (F-stain), Schirmer I test, and ocular surface disease index (OSDI) were evaluated before surgery and 2 weeks, 1 month, 2 months, and 3 months after surgery.
RESULTS
F-stain was significantly lower in group I than in group II at 2 weeks and 1 month (p < 0.05). There was no significant difference in uncorrected VA, BUT, Schirmer I test, or OSDI between the groups. However, group I showed a more effective pattern in dry eye.
CONCLUSIONS
Combination treatment with 0.05% cyclosporine A was helpful for early ocular surface stability in patients with dry eye after PRK.

Keyword

Cyclosporine A; Dry eye; Ocular surface stability; Photorefractive keratectomy; Refractive surgery

MeSH Terms

Cyclosporine*
Fluorescein
Humans
Photorefractive Keratectomy*
Refractive Surgical Procedures
Retrospective Studies
Tears
Visual Acuity
Cyclosporine
Fluorescein

Figure

• 

  Figure 1. Comparison of uncorrected visual acuity between the groups over time. (A) Group I and group II show a significant difference compared to preoperative values during the follow-up period (compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There was no statistically significant difference between the groups (compared by Mann-Whitney U-test). Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment. ∗p < 0.05.

• 

  Figure 2. Comparison of tear break-up time between the groups over time. (A) Group I shows a significant difference at 2 weeks compared with preoperative value, and group II at 2 weeks and 1 month (p < 0.05, compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There is no statistically significant difference between the groups during the follow-up period (compared by Student’s t-test). Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment. ∗p < 0.05.

• 

  Figure 3. Comparison of fluorescein staining score between the groups over time. (A) Group I shows a significant difference at 2 weeks compared with preoperative value, and group II at 2 weeks and 3 months (p < 0.05, compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There is a statistically significant difference between the groups at 2 weeks and 1 month (p < 0.05, compared by Student’s t-test). Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment. ∗p < 0.05.

• 

  Figure 4. Comparison of Schirmer I test between the groups over time. (A) Group I and group II shows no significant difference during the follow-up period compared with preoperative values (compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There is no statistically significant difference between the groups during the follow-up period (compared by Student’s t-test). Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment.

• 

  Figure 5. Comparison of ocular surface disease index between the groups over time. (A) Group I and group II shows no significant difference during the follow-up period compared with preoperative value (compared with preoperative value by repeated measure analysis of variance [ANOVA]). (B) There is no statistically significant difference between the groups during the follow-up period (compared by Student’s t-test). Group = conventional treatment + 0.05% cyclosporine A; Group I = conventional treatment + 0.05% cyclosporine A; Group II = conventional treatment.

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