J Korean Surg Soc.  2011 Sep;81(3):225-228. 10.4174/jkss.2011.81.3.225.

Tacrolimus related neurologic complication after pediatric kidney transplantation

• Kwun WH

• KMID: 2212202
• DOI: http://doi.org/10.4174/jkss.2011.81.3.225

Abstract

Recently significant neurotoxicity has been reported with the use of carcineurin inhibitors. An 11-year-old-girl had undergone a transplantation of kidney from her mother. On post-operative day 12, hypertension, headache, and left motor weakness (grade I) suddenly occurred. The brain-magnetic resonance imaging and magnetic resonance angiography showed acute cerebral infarction at subcortical white matter of the right hemisphere and multiple stenoses of both anterior cerebral artery and middle cerebral artery. While stopping tacrolimus treatment, we experienced clinical and radiological improvement. So, the neurological complications of this patient seem to have been caused by the use of tacrolimus.

Keyword

Neurotoxicity syndromes; Tacrolimus

MeSH Terms

Anterior Cerebral Artery
Cerebral Infarction
Constriction, Pathologic
Headache
Humans
Hypertension
Kidney
Kidney Transplantation
Magnetic Resonance Angiography
Middle Cerebral Artery
Mothers
Neurotoxicity Syndromes
Tacrolimus
Transplants
Tacrolimus

Figure

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  Fig. 1 Brain-magnetic resonance imaging and magnetic resonance angiography examination on post-operative day 12 showed acute cerebral infarction at subcortical white matter of right hemisphere and multiple stenoses of both anterior cerebral artery and middle cerebral artery.

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  Fig. 2 Brain-magnetic resonance imaging and magnetic resonance angiography examination on post-operative day 19 showed newly developed acute cerebral infarction on subcortical white matter of left hemisphere, cortex of left parietal lobe and mildly improving status of stenosis in both anterior cerebral artery and middle cerebral artery.

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  Fig. 3 Brain-magnetic resonance imaging and magnetic resonance angiography examination on post-operative day 29 showed improved status of multifocal acute infarction, no stenosis of both anterior cerebral artery and middle cerebral artery.

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