J Korean Acad Periodontol.  2009 Sep;39(3):321-329. 10.5051/jkape.2009.39.3.321.

The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite

• Gu SJ
• Sohn JY
• Lim HC
• Um YJ
• Jung UW
• Kim CS
• Lee YK
• Choi SH

• KMID: 2212146
• DOI: http://doi.org/10.5051/jkape.2009.39.3.321

Abstract

PURPOSE
The purpose of this study was to evaluate the bone regeneration of particulated hydroxyapatite(HA) and block type of hydroxyapatite graft in rabbit calvarial defects.
METHODS
An 8 mm calvarial circular defects were created in sixteen young adult New Zealand white male rabbits (weight 3.0~3.5 kg). Each defects were filled with Bio-Oss, particulated HA and block type HA. Sham surgery control defects were filled with blood clots. The pecimens were harvested at 4 weeks and 8 weeks for histologic and histomorphometric evaluation.
RESULTS
Histomorphometric analysis demonstrated statistical differences in defect closure, new bone formation, and bone density of the four groups. Block type of HA group showed increased bone formation and bone density at 4 weeks and 8 weeks compared with Bio-Oss group or sham surgery control group(p<0.05).
CONCLUSIONS
Block type of HA is an effective material for osteoconduction in rabbit calvarial defects, which may acts as a guide in use of these products in human application.

Keyword

bone regeneration; bone substitutes; hydroxyapatites

MeSH Terms

Bone Density
Bone Regeneration
Bone Substitutes
Durapatite
Humans
Hydroxyapatites
Male
Minerals
New Zealand
Osteogenesis
Rabbits
Salicylamides
Transplants
Young Adult
Bone Substitutes
Durapatite
Hydroxyapatites
Minerals
Salicylamides