J Korean Ophthalmol Soc.  2009 Jan;50(1):139-144. 10.3341/jkos.2009.50.1.139.

Analysis of Retinal Nerve Fiber Layer Thickness in Patients With Superior Segmental Optic Hypoplasia

• Seo JW
• Park IW
• Chung YS

• KMID: 2211909
• DOI: http://doi.org/10.3341/jkos.2009.50.1.139

Abstract

PURPOSE
To analyze the thickness of the peripapillary retinal nerve fiber layer (RNFL) in patients with superior segmental optic hypoplasia (SSOH) using optical coherence tomography (OCT).
METHODS
Ten eyes of 10 patients with SSOH and 20 eyes of 20 subjects as normal control were evaluated. The peripapillary RNFL thickness measured by Stratus OCT was compared between the two groups.
RESULTS
The mean RNFL thickness was significantly different between SSOH patients (72.35+/-14.77 micrometer) and normal subjects (111.61+/-6.62 micrometer) (p<0.001). The extent to which the RNFL thickness was below 5 percentile of normal subjects on the TSNIT graph was from the 41.7+/-15.53 to 110.1+/-7.47 scan number, which corresponded mainly with the superior nasal region. Moreover, in a clock-hour analysis, the peripapillary RNFL thic kness of the SSOH patients decreased significantly from 10 o'clock to 6 o'clock compared to normal subjects (p<0.01).
CONCLUSIONS
Peripapillary RNFL thickness in patients with SSOH was reduced in the superior, nasal, and inferior regions. Further studies involving larger populations of patients should be performed to verify these findings.

Keyword

Optical coherence tomography (OCT); RNFL thickness; Superior segmental optic hypoplasia (SSOH); Topless optic disc syndrome

MeSH Terms

Eye
Humans
Nerve Fibers
Retinaldehyde
Tomography, Optical Coherence
Retinaldehyde

Figure

• 

  Figure 1. The right eye with superior segmental optic hypoplasia. Representative color disc photograph (A) and retinal nerve fiber layer (RNFL) photograph (B) showing neuroretinal rim thinning in the superior nasal region with corresponding RNFL defects. (C) Humphrey automated perimetry shows a characteristic inferior visual field defect. (D) Optical coherence tomography (OCT) scan shows the peripapillary RNFL thinning in superior region of the right eye.

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  Figure 2. The peripapillary retinal nerve fiber layer (RNFL) thickness assessed by optical coherence tomography is shown for clock hour around optic nerve head. Open squares represent mean RNFL thickness from 20 eyes of normal subjects, and solid squares from 10 eyes with superior segmental optic hypoplasia (SSOH). Error bars indicate 1 standard deviation from the mean. Asterisks indicate a significant difference of RNFL thickness between normal subjects and SSOH (p<0.01).

Reference

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