J Pathol Transl Med.
2016 Jan;50(1):10-16. 10.4132/jptm.2015.09.15.
Menetrier's Disease: Its Mimickers and Pathogenesis
- Affiliations
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- 1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. kay.washington@vanderbilt.edu
- 2Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
- 3Department of Veterans Affairs Medical Center, Nashville, TN, USA.
- KMID: 2211396
- DOI: http://doi.org/10.4132/jptm.2015.09.15
Abstract
- Menetrier's disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Menetrier's disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Menetrier's disease and the role of EGFR signaling in Menetrier's disease.
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