J Korean Soc Radiol.  2010 Jan;62(1):11-15. 10.3348/jksr.2010.62.1.11.

Multiple Synchronous Central Giant Cell Granulomas of the Maxillofacial Region: A Case Report

• Kang MS
• Kim HJ

• KMID: 2208988
• DOI: http://doi.org/10.3348/jksr.2010.62.1.11

Abstract

Multifocal central giant cell granulomas (CGCG) in the maxillofacial region are suggestive of systemic disease such as hyperparathyroidism or an inherited syndrome such as Noonan-like multiple giant cell lesion syndrome. Only 5 cases of multifocal CGCGs in the maxillofacial region without any concomitant systemic disease have currently been reported. We report here on an unusual case of 17-year-old man who presented with multifocal CGCGs of the bilateral posterior mandible and right maxilla and he was without any concomitant systemic disease.

MeSH Terms

Adolescent
Giant Cells
Granuloma, Giant Cell
Humans
Hyperparathyroidism
Jaw Diseases
Mandible
Maxilla
Neoplasms, Multiple Primary

Figure

• 

  Fig. 1 A. The coronal CT scan with a bone window setting shows a relatively well defined, heterogeneous isodense mass (arrows) with diffuse mineralized septa (arrowheads) in the right maxilla. B. The axial CT scan with a bone window setting shows expansile remodeling with cortical thinning of the medial and lateral walls of the maxillary antrum (arrowheads). The mass eroded the adjacent bony structures, such as the anterior wall of the sphenoid sinus (black arrow) and the mass extends to the right antrum and the posterior nasal cavity (white arrow). C. The axial CT scan (below the level of B) shows multiple osteolytic lesions (arrows) with cortical expansion, bone thinning and mineralized septa (arrowheads) in the bilateral posterior mandible.

• 

  Fig. 2 A-F. The multiple masses (arrows) in the right maxillary sinus and bilateral posterior mandible show low signal intensity on the T1-weighted images (A, B), heterogeneous low to intermediate signal intensity on the T2-weighted images (C, D) and intense enhancement of the masses (E, F) after the administration of contrast agent.

• 

  Fig. 3 The biopsy specimen shows several multinucleated giant cells within a background of ovoid and spindle-shaped mesenchymal cells (hematoxylin and eosin staining, magnification×400).

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