J Korean Soc Magn Reson Med.
2007 Dec;11(2):103-109.
Assessment of Non-permeability of Gd-DTPA for Dynamic Susceptibility Contrast in Human Brain: A Preliminary Study Using Non-linear Curve Fitting
- Affiliations
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- 1Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Korea. bychoe@catholic.ac.kr
- 2Department of Radiology, East-west Neo Medical Center, Kyung-Hee University, Korea.
- 3Department of Radiology, Seoul Health College, Korea.
- 4Department of Radiology, College of Medicine, The Catholic University of Korea, Korea.
Abstract
- To develop an advanced non-linear curve fitting (NLCF) algorithm for performing dynamic susceptibility contrast study of the brain. The first pass effects give rise to spuriously high estimates of Ktrans for the voxels that represent the large vascular components. An explicit threshold value was used to reject voxels. The blood perfusion and volume estimation were accurately evaluated in the T2*-weighted dynamic contrast enhanced (DCE)-MR images. From each of the recalculated parameters, a perfusion weighted image was outlined by using the modified non-linear curve fitting algorithm. The present study demonstrated an improvement of an estimation of the kinetic parameters from the DCE T2*-weighted magnetic resonance imaging data with using contrast agents.
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