J Korean Ophthalmol Soc.  2003 Jan;44(1):81-85.

The Changes in Intraocular Pressure Following the Combined Treatment of Systemic Acetazolamide and Topical Dorzolamide

• Park TK
• Moon JI
• Park CK

Abstract

PURPOSE
This study is to determine whether topical dorzolamide and systemic acetazolamide have an additive effect on the changes in intraocular pressure (IOP) in patients with open angle glaucoma. METHODS: Twenty eyes of 10 patients being treated with only acetazolamide (Group 1) and 20 eyes of 10 patients being treated with only dorzolamide (Group 2) were included in this study. Dorzolamide was additionally applied three times a day to Group 1 and acetazolamide 250 mg three times a day was additionally given to Group 2. Changes in intraocular pressure and complications due to overdose of carbonic anhydrase inhibitors (CAIs) were checked 1, 2, and 4 weeks after the additional treatment. RESULTS: The IOP was reduced 1.0+/-2.9% (N=20) (p>0.05) from the baseline pressure checked before the additional treatment in Group 1 and 13.2+/-3.6% (N=16) (p<0.01) in Group 2. No significant complication due to CAI usage was observed. CONCLUSIONS: In patients with open angle glaucoma, combination therapy of systemic and topical CAIs was effective only when additional systemic CAI was given to the cases using topical agents.

Keyword

Acetazolamide; Dorzolamide; Open angle glaucoma

MeSH Terms

Acetazolamide*
Carbonic Anhydrase Inhibitors
Glaucoma, Open-Angle
Humans
Intraocular Pressure*
Acetazolamide
Carbonic Anhydrase Inhibitors