J Korean Soc Transplant.  2015 Dec;29(4):194-199. 10.4285/jkstn.2015.29.4.194.

The Effects of Normal Saline Solution versus Hartmann's Solution on the Acid-base and Electrolytes Status and Renal Function after Kidney Transplantation

• Kim MY
• Jeon NY
• Hyun SK
• Kim HT
• Cho WH
• Park UJ

• KMID: 2202604
• DOI: http://doi.org/10.4285/jkstn.2015.29.4.194

Abstract

BACKGROUND
The purpose of this study was to elucidate the effects of fluid on the acid-base and electrolytes status and renal function after kidney transplantation (KT).
METHODS
We retrospectively analyzed 103 patients who underwent KT. Analyses were performed separately according to the donor type (living, 52; deceased, 51). In the living donor KT group, 28 patients received normal saline solution (NS) and 24 patients received Hartmann's solution (HS). In the deceased donor KT group, 27 patients received NS, and 24 received HS. The acid-base and electrolyte status, urine volume, and renal function between patients receiving NS and patients receiving HS were compared in each group.
RESULTS
Regardless of donor type, there were no differences in potassium, pH, base excess, PCO2 and HCO3 between HS and NS on immediate postoperative and postoperative day 1. However, changes to neutral acid-base balance in terms of pH, HCO3, and base excess were significantly higher in HS than in NS. In living donor KT, NS increased serum potassium and chloride significantly during fluid therapy. On postoperative day 7, renal function showed no difference between two groups but urine volume was significantly larger in NS than in HS.
CONCLUSIONS
HS does not increase the incidence of hyperkalemia after KT. The use of HS resulted in less metabolic acidosis than the use of NS. Renal function was similar but polyuria was more severe in patients who received NS than in those who received HS.

Keyword

Kidney transplantation; Fluid therapy; Electrolytes; Acid-base; Hartman's solution; Normal saline solution

MeSH Terms

Acid-Base Equilibrium
Acidosis
Electrolytes*
Fluid Therapy
Humans
Hydrogen-Ion Concentration
Hyperkalemia
Incidence
Kidney Transplantation*
Kidney*
Living Donors
Polyuria
Potassium
Retrospective Studies
Sodium Chloride*
Tissue Donors
Electrolytes
Potassium
Sodium Chloride

Reference

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