J Korean Rheum Assoc.
2004 Dec;11(4):411-416.
A Case of Neuropsychiatric Lupus Presenting as Guillain-Barre Syndrome and Cerebral Infarction
- Affiliations
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- 1Division of Rheumatology, Departments of Internal Medicine Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea. drkiss@gnah.co.kr
- 2Departments of Neurology Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
Abstract
- Systemic lupus erythematosus (SLE) is a disease of unknown etiology in which tissues and cells damaged by pathogenic autoantibodies and immune complexes. Nervous system involvement in patients with SLE encompasses a wide spectrum of neurologic and psychiatric features and the frequency of neuropsychiatric manifestations has been estimated at around 25% to 70%. American College of Rheumatology Ad Hoc Committee on neuropsychiatric lupus nomenclature developed case definitions for 19 different neuropsychiatric manifestations observed in SLE in 1999. Among them, Guillain-Barre syndrome and cerebral infarction are very rare neuropsychiatric manifestation. We experienced a 28-year-old woman with neuropsychiatric lupus which presented as Guillain-Barre syndrome and cerebral infarction. She was recovered after treatment with intravenous immunoglobulin, high dose methylprednisolone, cyclophosphamide and anticoagulants.
Keyword
MeSH Terms
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Adult
Anticoagulants
Antigen-Antibody Complex
Autoantibodies
Cerebral Infarction*
Cyclophosphamide
Female
Guillain-Barre Syndrome*
Humans
Immunoglobulins
Lupus Erythematosus, Systemic
Methylprednisolone
Nervous System
Rheumatology
Anticoagulants
Antigen-Antibody Complex
Autoantibodies
Cyclophosphamide
Immunoglobulins
Methylprednisolone
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