J Korean Radiol Soc.  1994 May;30(5):893-900.

An Experimental Study on Renal Functional Disturbance in Rabbits After Acute Ureteral Obstruction With Dynamic Gd-DTPA Enhanced MR Imaging

• Shin KJ
• Chung EC
• Sik Rhee C

Abstract

PURPOSE
To evaluate the anatomic and functional change in acutely obstructed kidneys, and the probability of functional recovery after resolving the obstruciton.
MATERIALS AND METHODS
There were 5 animal groups(6 rabbits in each group)-normal control group, 4 acute ureteral obstruction group. Each of the latter group was imaged with Gd-DTPA enhanced dynamic MR 2, 6, 24, and 48 hours after ligation of the left proximal urter, respectively. We compared the findings of dynamic MR imaging and histopathological findings.
RESULTS
We could observe centripetal movement of dark band pattern which could be defined as 3 phasesrenal cortex, outer medulla, and inner medulla in normal rabbits. The appearance of the dark band pattern was delayed or absent in ureteral obstruction group with a linear relationship to the duration of the obstruction.
CONCLUSION
Gd-DTPA enhanced MR can be used to differentiate acute obstructive nephropathy from other causes of nephropathy and foretell the prognosis of the obstruction.

MeSH Terms

Animals
Gadolinium DTPA*
Kidney
Ligation
Magnetic Resonance Imaging*
Prognosis
Rabbits*
Ureter*
Ureteral Obstruction*
Gadolinium DTPA