J Korean Soc Menopause.  2011 Aug;17(2):68-74.

SSRIs and SNRIs for Management of Hot Flushing

Affiliations
  • 1Department of Obstetrics and Gynecology, The Catholic University of Korea, School of Medicine, Seoul, Korea. janghkim@catholic.ac.kr

Abstract

For postmenopausal women who fear hormone therapy, women 60 years of age with continuous, severe hot flushing or women with a history of breast cancer, we should consider selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs) as therapeutic agents. Base on the results from a meta-analysis and clinical trials regarding hot flushing, paroxetine and the conetrolled-release formultation of paroxetine have been shown to effectively reduce hot flushing by 30~40% and 60~70%, respectively, and 13~41% more reductions as compared to placebo. Venlafaxine reduced hot flushes by 30~60% (133% reductions compared to placebo), and desvenlafaxine reduced hot flushes by 30~70%. Fluoxetine and citalopram were shown to be less effective than paroxetine and venlafaxine, by 20% (113% reductions compared to placebo) and 40~50%, respectively. Sertraline reduced hot flushes 3~18% compared to the placebo group, but was considered ineffective. Citalopram (20 mg), paroxetine (10 mg), venlafaxine (37.5~150 mg), and desvenlafaxine (100~200 mg) not only reduced vasomotor symptoms, but demonstrated additional beneficial outcomes with respect to sleep disturbances, mood, the vigor index, and improved quality of life. Citalopram (20 mg), fluoxetine (20 mg), paroxetine (10 mg), venlafaxine (75~150 mg), and desvenlafaxine (150 mg) are recommended at the corresponding doses after weighing the risks and benefits of these medications. SSRIs and SNRIs were shown to interrupt the conversion of tamoxifen into the active metabolite, endoxifen, and thus SSRIs and SNRIs must not be used in breast cancer patients who are taking tamoxifen. Paroxetine suppressed vasomotor symptoms most potently, followed by fluoxetine, sertraline, citalopram, and venlafaxine.

Keyword

Hot flush; Menopause; Serotonin norepinephrine reuptake inhibitor; Selective serotonin reuptake inhibitor

MeSH Terms

Breast Neoplasms
Citalopram
Cyclohexanols
Female
Fluoxetine
Flushing
Humans
Menopause
Norepinephrine
Paroxetine
Quality of Life
Risk Assessment
Serotonin
Serotonin Uptake Inhibitors
Sertraline
Tamoxifen
Desvenlafaxine Succinate
Venlafaxine Hydrochloride
Citalopram
Cyclohexanols
Fluoxetine
Norepinephrine
Paroxetine
Serotonin
Serotonin Uptake Inhibitors
Sertraline
Tamoxifen
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