J Korean Soc Ther Radiol.  1993 Jun;11(1):103-108.

The Role of the Postoperative Adjuvant Radiation Therapy to Primary Site in Rectal Cancer Patients with Synchronous Liver Metastasis

• Seong JS
• Shin HS
• Lee HS
• Kim GE
• Suh CO
• Loh JK
• Kim WC
• Pyo HR

Abstract

Among the patients with rectal cancer who entered Yonsei University Hospital for management from Jan. 1980 to Dec. 1990, we selected 23 subjects who were received surgical resection of tumor in rectum, and who proved to have liver metastasis during the diagnostic work-up, at the time of the operation, or within 3 months after starting definitive treatment. With those subjects, we investigated the role of radiation therapy by comparison of the treatment results of the patients without radiation therapy (S group) with those of the patients with radiation therapy to the primary site (S+R group). The local control rates of S group and S+R group were 64% and 89%, and 2-year survival rates were 50% and 78%, respectively. Although there was not statistically meaningful difference, local control rate and 2-year survival rate were higher in the group with radiation therapy to primary site than that without radiation therapy. The 2-year survival rates of the case with resection of the liver and the case without it were 03.6% and 58.3% respectively, which was not statistically significant. Also, the 2-year survival rate of the case with sustained local control was higher than that of the case with local failure, which was statistically significant(70.5% and 16.7%, p<0.005). From the above results, it is thought that radiation therapy to the primary site might improve the local control rate even in the patients with liver metastasis, which seems to be correlated to the higher survival rate.

Keyword

Rectal cancer; Synchronous liver metastasis; Radiotherapy

MeSH Terms

Humans
Liver*
Neoplasm Metastasis*
Radiotherapy
Rectal Neoplasms*
Rectum
Survival Rate