J Korean Soc Ther Radiol.  1995 Sep;13(3):267-276.

Second Malignanat Solid Neoplasms in Children Treated with Radiotherapy: Report of Two Cases and Review of Literature

• Chung EJ
• Suh CO
• Kim GE
• Lyu CJ
• Kim BS

Abstract

Radiotehrapy and chemotherapy can effectively control cancer but can also cause new second cancers to develop as long-term complications especially in childhood cancer. We experienced two patients with second malignant solid neoplasm who had been treated with radiation and chemotherapy for childhood cancers. One female patients with rhabdomyosarcoma of the right popliteal fossa was treated with radiotherapy at total dose of 54 Gy. Three years and seven months later, osterosarcoma developed in the field of radiation therapy. The other male patient with non-Hodgkin's lymphoma of the small bowel was treated with radiotherapy and leiomyosarcoma developed in the field of radiotherapy 18 years later. We reviewed the literature of the second malignant neoplasm in children in respect of risk factors. The risk for a second primay cancer following radiotherapy or chemotherapy emphasizes the need for life long follow-up of patients receiving such treatments. Particularly patients treated for childhood cancers.

Keyword

Second cancer; Childhood cancer; Radiotherapy

MeSH Terms

Child*
Drug Therapy
Female
Follow-Up Studies
Humans
Leiomyosarcoma
Lymphoma, Non-Hodgkin
Male
Neoplasms, Second Primary
Radiotherapy*
Rhabdomyosarcoma
Risk Factors