J Korean Soc Pediatr Endocrinol.
2007 Jun;12(1):77-81.
Growth Hormone Therapy in Russell-Silver Syndrome
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- 1Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea. kimhs@dsmc.or.kr
Abstract
- Russell-Silver syndrome is characterized by low birth weight, growth retardation, delayed bone age, asymmetry, abnormal sexual development, cranio-facial disproportion, short little finger and clinodactyly. Short stature is the major concern, so there have been interests treating Russell-Silver syndrome with human growth hormone. However, there are no large-scale controlled studies to confirm the effectiveness of growth hormone therapy until now because of the rarity of this disorder. In Korea, we cannot find reports dealing with growth hormone treatment in Russell-Silver syndrome. We present three children with Russell-Silver syndrome who showed accelerated growth with growth hormone treatment.
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