J Korean Soc Neonatol.  2011 May;18(1):76-81. 10.5385/jksn.2011.18.1.76.

Effects of Early Parenteral Nutrition for Extremely Low Birth Weight Infants

• Ahn SY
• Shin JH
• Shin JH
• Sung SI
• Jung JM
• Kim JK
• Chang YS
• Park WS

• KMID: 2188468
• DOI: http://doi.org/10.5385/jksn.2011.18.1.76

Abstract

PURPOSE
The object of this study was to evaluate the efficacy of early total parenteral nutrition with early amino acid in extremely low birth weight infant (ELBWI).
METHODS
We retrospectively analyzed the medical records of all ELBWIs who were born and admitted to Samsung Medical Center from January 2003 to December 2003 and January 2009 to December 2009 and alive at the time of discharge. Data for nutritional status and morbidities were compared between period 1 (2003, n=22), in which parenteral nutritional support was started gradually over several days and period 2 (2009, n=38), in which parenteral nutrition with amino acid was started as soon as possible after birth.
RESULTS
Compared to period 1, birth weight and Apgar score were lower in period 2. The intake amount of glucose, amino acid and total calorie was higher and the level of blood urea nitrogen was increased more from 7th day to 14th day after birth in period 2 when compared than period 1. The weight gain velocity was faster at 7th and 14th postnatal day in period 2. There were no differences in the incidence of necrotizing enterocolitis, moderate to severe bronchopulmonary dysplasia, and severe intraventricular hemorrhage (> or = Gr III) between two periods but, the incidence of periventricular leukomalacia(PVL) was significantly lower in period 2.
CONCLUSION
Early initiation of total parenteral nutrition with early amino acid in ELBWIs was beneficial at weight gain with lowering catabolism and increasing anabolism. And it could be related with reducing the incidence of PVL.

Keyword

Extremely low birth weight infants; Parenteral nutrition; Growth

MeSH Terms

Apgar Score
Birth Weight
Blood Urea Nitrogen
Bronchopulmonary Dysplasia
Enterocolitis, Necrotizing
Glucose
Hemorrhage
Humans
Incidence
Infant
Infant, Extremely Low Birth Weight
Infant, Low Birth Weight
Infant, Newborn
Medical Records
Nutritional Status
Nutritional Support
Parenteral Nutrition
Parenteral Nutrition, Total
Parturition
Retrospective Studies
Weight Gain
Glucose