J Korean Assoc Maxillofac Plast Reconstr Surg.  2010 Nov;32(6):497-503.

Arthritis on Temporomandibular Joint in Rabbit by Collagenase Injection

• Song DS
• Kim KH
• Lee JY
• Jung E
• Ahn SW
• Song JW
• Kim CH
• Shin SH
• Chung IK

Abstract

PURPOSE
The purpose of this study is to induce artificial arthritis on rabbit TMJ by injecting collagenase.
MATERIALS AND METHODS
An experimental animal model of arthritis induced by surgical method or intra-articular injection of chemical agent like LDH, papain, ketorolac. Surgical method is complex and needs a long time in inducing arthritis. Intra-articular injection of chemical agent like LDH, papain, ketorolac is simple. But chemical agent like LDH, papain, ketololac needs multiple injections to induce arthritis and mechanism inducing arthritis was known. Collagenase destroys helical domain of type II collagen in extracellular matrix produced by chondrocyte and then induces arthritis.
RESULTS
Four weeks after injection of 2.0 mg collagenase, we could see histologic change like arthritis. In other groups, we couldn't see arthritis-like change.
CONCLUSION
In our study, we produce arthritis on temporomandibular joint of rabbit by using injection of collagenase in temporomandibular joint of rabbit. And this experimental osteoarthritis is a useful animal model.

Keyword

TMJ; Osteoarthritis; Collagenase; Rabbit

MeSH Terms

Arthritis
Chondrocytes
Collagen Type II
Collagenases
Extracellular Matrix
Injections, Intra-Articular
Ketorolac
Models, Animal
Osteoarthritis
Papain
Temporomandibular Joint
Collagen Type II
Collagenases
Ketorolac
Papain