J Korean Assoc Maxillofac Plast Reconstr Surg.  1998 Nov;20(4):275-278.

An experimental study on the bone regeneration of tibial bone defect

  • 1Department of Oral & Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University.


Recently, the clinical applications of the autogenous cancellous bone from the proximal tibial metaphysis show satisfactory results in the repair of maxillofacial bony defect or deformity. The proximal tibia has the potential to yield viable cancellous bone with a minimum of morbidity. The purpose of this study was to investigate the regeneration of a full thickness proximal tibial bone defect with covering or uncovering of cortical bone. The follow-up periods were 4, 8, and 12 weeks. Bone defect of right side was uncovered and left side was covered with cortical bone. In the experimental group (uncovered cortical bone) at 12 weeks, the inside of defect was filled to normal marrow tissue. The cortical bone defect was united of inner, outer callus at 4, 8 weeks in both study group. At 12 weeks, the cortical bone defect was remodeled and invaded by osteoclast (giant cell) in experimental group. In the experimental specimen at 12 weeks, the regenerating tissue of bone defect was not differ from the control grou.

MeSH Terms

Bone Marrow
Bone Regeneration*
Bony Callus
Congenital Abnormalities
Follow-Up Studies
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