J Korean Breast Cancer Soc.  1998 Dec;1(2):208-214. 10.4048/jkbcs.1998.1.2.208.

Expression of Sialosyl-Tn Antigen in Breast Cancer & Its Correlation with Prognostic Parameters

• Kwon YT
• Cho SH
• Kim YH
• Kim SS
• Hong SH
• Kim JM
• Choi SR

• KMID: 2173679
• DOI: http://doi.org/10.4048/jkbcs.1998.1.2.208

Abstract

To determine whether the expression of Sialosyl-Tn antigen may have its putative relationship as an established or potentially useful clinicopathologic prognostic parameter in breast cancer, we evaluated 110 patients with invasive breast carcinoma, using formalin-fixed, paraffin-embedded tissue sections. STn antigen was detected by the HB-STn antibody using an avidin-biotin-peroxidase method. The parameters studied were tumor size, nodal status, stage, histologic grade, ER/PR expression, DNA ploidy and S-phase fraction. STn expression was observed in 42 patients (38.2%) with breast cancer. The expression rate of STn was associated with axillary node metastasis. A tendency towards an association between STn expression and tumor size or TNM stage. There was no relationship between STn expression and histologic grade, ER/PR expression, DNA ploidy and S-phase fraction. We conclude that the detection of STn expression may be useful for predicting lymph node metastasis.

Keyword

Sialosyl-Tn; Breast Cancer; Prognostic factors

MeSH Terms

Breast Neoplasms*
Breast*
DNA
Humans
Lymph Nodes
Neoplasm Metastasis
Ploidies
DNA