Chonnam Med J.  2008 Dec;44(3):177-179. 10.4068/cmj.2008.44.3.177.

Familial Focal Acral Hyperkeratosis Associated with Hyperthyroidism

• Akagi A
• Tanioka M
• Araki E
• Takahashi
• Miyachi Y
• Utani A

• KMID: 2172298
• DOI: http://doi.org/10.4068/cmj.2008.44.3.177

Abstract

We present a case of familial disease, focal acral hyperkeratosis (FAH), associated with hyperthyroidism that subsequently turned into thiamazole-induced hypothyroidism. To our knowledge, there have been no reports that describe the association between FAH and hyperthyroidism. FAH is a rare type of marginal papular keratoderma and its etiology is still unknown. In the present case, we observed that thiamazole- induced secondary hypothyroidism was accompanied by a rapid increase of skin lesions. Therefore, we speculate that there is a causal relationship between the deterioration of FAH and the altered thyroid function by the usage of thiamazole.

Keyword

Epidermolytic hyperkeratosis; Hyperthyroidism; Thiamazole

MeSH Terms

Hyperkeratosis, Epidermolytic
Hyperthyroidism
Hypothyroidism
Methimazole
Skin
Thyroid Gland
Methimazole

Figure

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  Fig. 1 Multiple, yellow-tinged, flat-topped papules on the fingers.

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  Fig. 2 Pronounced orthohyperkeratosis within a cuplike depression of the epidermis (H&E, ×100).

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