Ann Dermatol.  2006 Jun;18(1):18-20. 10.5021/ad.2006.18.1.18.

Depigmented Scrotal Extramammary Paget's Disease in a Patient with Rectal Cancer: A Case of Coincidental Double Primary Adenocarcinomas

Affiliations
  • 1Department of Dermatology, St. Mary's Hospital, The Catholic University of Korea, Korea.
  • 2Department of Dermatology, Daejeon St. Mary's Hospital, The Catholic University of Korea, Korea. ostksy @yahoo.co.kr

Abstract

Extramammary Paget's disease (EMPD) typically presents as an eczematous, eroded or crusted plaque. Only a few cases with depigmentation have been reported. We herein report a patient with a depigmented scrotal patch as the sole finding of EMPD. Since he had concurrent rectal cancer, we stained the tissue with gross cystic disease fluid protein-15 (GCDFP-15) and cytokeratin 20 (CK20) in order to differentiate primary/secondary EMPD. This case represents coincidental primary EMPD and rectal cancer, of which the initial features of EMPD were unusual.

Keyword

Extramammary Paget's disease; Depigmented patch; Concurrent rectal cancer; GCDFP-15; CK20

MeSH Terms

Adenocarcinoma*
Cytochrome P-450 CYP1A1
Humans
Keratin-20
Paget Disease, Extramammary*
Rectal Neoplasms*
Cytochrome P-450 CYP1A1
Keratin-20
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