Ann Dermatol.  2011 Dec;23(Suppl 3):S319-S321. 10.5021/ad.2011.23.S3.S319.

Generalized Granuloma Annulare in Infancy Following Bacillus Calmette-Guerin Vaccination

• Lee SW
• Cheong SH
• Byun JY
• Choi YW
• Choi HY
• Myung KB

• KMID: 2171861
• DOI: http://doi.org/10.5021/ad.2011.23.S3.S319

Abstract

Generalized granuloma annulare (GGA) is a rare benign granulomatous dermatosis characterized by disseminated necrobiotic dermal papules. Histologically, it presents as a lymphohistiocytic granuloma associated with varying degrees of connective tissue degeneration. It usually occurs in adults and rarely affects infants. Herein, we report an interesting case of GGA which occurred in a 3 month-old girl in association with Bacillus Calmette-Guerin vaccination.

Keyword

BCG vaccine; Granuloma annulare; Infant

MeSH Terms

Adult
Bacillus
BCG Vaccine
Connective Tissue
Granuloma
Granuloma Annulare
Humans
Infant
Skin Diseases
Vaccination
BCG Vaccine

Figure

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  Fig. 1 (A) Well-demarcated, slightly erythematous firm papules are present on the trunk. (B) Close-up view. (C) The Bacillus Calmette-Guerin injected site (left upper arm) shows post-inflammatory hyperpigmentation; the papules originated at this site.

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  Fig. 2 Pale eosinophilic granular area of degenerated collagen bundles is surrounded by dense infiltration of lymphocytes, histiocytes and multinucleated giant cells in the dermis. (A) H&E, ×40, (B) H×E, ×200.

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