Korean J Dermatol.  2014 Apr;52(4):264-268.

Three Cases of Generalized Granuloma Annulare in Infancy Following Bacillus Calmette-Guerin Vaccination

• Kim SW
• Kong TS
• Han TY
• Lee JH
• Son SJ

Abstract

Generalized granuloma annulare is a rare benign granulomatous dermatosis characterized by disseminated necrobiotic dermal papules forming an annular or nonannular configuration. It usually occurs in adults and rarely affects infants. Histologically, it presents as a lymphohistiocytic granuloma associated with varying degrees of connective tissue degeneration. Clinical associations between generalized granuloma annulare and diabetes mellitus, thyroid disease, malignancy, infection, and vaccination have been reported. There are a few cases reports of generalized granuloma annulare associated with Bacillus Calmette-Guerin (BCG) vaccination. Herein, we report three cases of generalized granuloma annulare following BCG vaccination in infants.

Keyword

BCG vaccine; Granuloma annulare; Infant

MeSH Terms

Adult
Bacillus*
BCG Vaccine
Connective Tissue
Diabetes Mellitus
Granuloma
Granuloma Annulare*
Humans
Infant
Mycobacterium bovis
Skin Diseases
Thyroid Diseases
Vaccination*
BCG Vaccine