Clin Exp Vaccine Res.  2013 Jul;2(2):135-139. 10.7774/cevr.2013.2.2.135.

Efficacy of a commercial live attenuated Lawsonia intracellularis vaccine in a large scale field trial in Korea

• Park S
• Lee JB
• Kim KJ
• Oh YS
• Kim MO
• Oh YR
• Hwang MA
• Lee JA
• Lee SW

• KMID: 2167724
• DOI: http://doi.org/10.7774/cevr.2013.2.2.135

Abstract

PURPOSE
Porcine proliferative enteropathy (PPE) is known as one of the most important risk factors causing economic losses in swine industry worldwide. This study was conducted to evaluate the efficacy of a commercial oral attenuated Lawsonia intracellularis vaccine (Enterisol Ileitis) against PPE under a commercial pig farm condition in Korea.
MATERIALS AND METHODS
Thirty two-day-old 672 piglets were randomly allocated into vaccinated and control groups. All piglets in the vaccinated group were inoculated with a commercial attenuated L. intracellularis vaccine as following the manufacturer's instruction. Body weights of all pigs in both groups were measured on the vaccination day and 6, 14, and 20 weeks post vaccination and an average daily weight gain (ADWG) was calculated. Health status was observed biweekly during the whole trial.
RESULTS
The vaccinated group showed significantly higher body weight (p<0.05) and ADWG (p<0.05) than those of the control group. The vaccinated group had significantly reduced impairments in activity, growth, defecation frequency, and stool hardness (p<0.05). Additional health benefits and improved weight gain by the vaccination produced a 4.2:1 return of investment, and the higher gross margin was $4.80 per pig.
CONCLUSION
Our finding suggests that the L. intracellularis vaccine program has effects on the substantial health and economic benefits in the Korean swine industry.

Keyword

Lawsonia intracellularis; Intestinal diseases; Ileitis; Vaccines; Swine

MeSH Terms

Body Weight
Defecation
Hardness
Ileitis
Insurance Benefits
Intestinal Diseases
Investments
Korea
Lawsonia Bacteria
Risk Factors
Swine
Vaccination
Vaccines
Weight Gain
Vaccines

Figure

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  Fig. 1 Antibody levels against Lawsonia intracellularis determined by enzyme-linked immunosorbent assay (ELISA) after vaccination.

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