Cancer Res Treat.  2013 Sep;45(3):162-171.

Survival of Korean Adult Cancer Patients by Stage at Diagnosis, 2006-2010: National Cancer Registry Study

Affiliations
  • 1The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea. astra67@ncc.re.kr
  • 2Molecular Epidemiology Branch, National Cancer Center, Goyang, Korea.

Abstract

PURPOSE
Although the cancer stage at diagnosis is the most important prognostic factor for patients' survival, there are few population-based estimates of stage-specific survival outcome, especially in Asian countries. Our study aims to estimate stage-specific survival for Korean patients.
MATERIALS AND METHODS
We analyzed the Korea National Cancer Incidence Database data on 626,506 adult patients aged > or = 20 years, who were diagnosed between 2006 and 2010 with stomach, colorectal, liver, lung, breast, cervix, prostate, and thyroid cancers. Patients were followed up to December 2011, and the 5-year relative survival rates (RSRs) were calculated for gender and age group by Surveillance, Epidemiology, and End Results (SEER) stage at diagnosis.
RESULTS
The 5-year RSRs for all localized-stage cancers, except for lung and liver, exceeded 90% with that for thyroid cancer being the highest at 100.4%. These values for distant stage liver, lung, and stomach cancers were very dismal at 2.5%, 4.8%, and 5.5%, respectively, while it was 69.1% for thyroid cancer, and was in the range of 18.3-36.4% for colorectal, cervix, breast and prostate cancers. Overall, the 5-year RSRs for all cancer types decreased with aging across all the disease stages with exception of prostate cancer, which suggests biologic difference in these cancer types in a young age group. When compared with US SEER data, Korean patients had better stage-specific survival rates for stomach, colorectal, liver, and cervical cancers.
CONCLUSION
Korean cancer patients showed relatively favorable stage distribution and 5-year RSRs, which suggests potential contribution of the national cancer screening program.

Keyword

Korea; Neoplasms; Survival; Stage; Cancer Registry

MeSH Terms

Adult
Aged
Aging
Asian Continental Ancestry Group
Breast
Cervix Uteri
Early Detection of Cancer
Female
Humans
Incidence
Korea
Liver
Lung
Prostate
Prostatic Neoplasms
Stomach
Stomach Neoplasms
Survival Rate
Thyroid Gland
Thyroid Neoplasms

Figure

  • Fig. 1 Distribution of 5-year relative survival rates by Surveillance, Epidemiology, and End Results (SEER) summary staging and age at diagnosis.


Reference

1. Jung KW, Won YJ, Kong HJ, Oh CM, Seo HG, Lee JS. Cancer statistics in Korea: incidence, mortality, survival and prevalence in 2010. Cancer Res Treat. 2013; 45:1–14. PMID: 23613665.
Article
2. Kwong A, Mang OW, Wong CH, Chau WW, Law SC. Hong Kong Breast Cancer Research Group. Breast cancer in Hong Kong, Southern China: the first population-based analysis of epidemiological characteristics, stage-specific, cancer-specific, and disease-free survival in breast cancer patients: 1997-2001. Ann Surg Oncol. 2011; 18:3072–3078. PMID: 21847700.
Article
3. Sankaranarayanan R, Swaminathan R, Brenner H, Chen K, Chia KS, Chen JG, et al. Cancer survival in Africa, Asia, and Central America: a population-based study. Lancet Oncol. 2010; 11:165–173. PMID: 20005175.
Article
4. Jung KW, Won YJ, Park S, Kong HJ, Sung J, Shin HR, et al. Cancer statistics in Korea: incidence, mortality and survival in 2005. J Korean Med Sci. 2009; 24:995–1003. PMID: 19949651.
Article
5. Thornton M. Standards for Cancer Registries, Vol. II. Data standards and data dictionary, record layout version 12.1. 15th ed. Springfield: Notrh American Association of Central Cancer Registries;2010.
6. The Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2010. Seoul: Ministry of Health and Welfare;2012.
7. Shin HR, Won YJ, Jung KW, Kong HJ, Yim SH, Lee JK, et al. Nationwide cancer incidence in Korea, 1999~2001: first result using the National Cancer Incidence Database. Cancer Res Treat. 2005; 37:325–331. PMID: 19956367.
Article
8. World Health Organization. International Classification of Disease for Oncology. 3rd ed. Geneva: World Health Organization;2000.
9. World Health Organization. Manual of the international statistical classification of diseases, injuries, and causes of death. Geneva: World Health Organization;1992.
10. Brenner H, Gefeller O. An alternative approach to monitoring cancer patient survival. Cancer. 1996; 78:2004–2010. PMID: 8909323.
Article
11. Ederer F, Heise H. Instructions to IBM 650 programmers in processing survival computations. Methodological note 10. Bethesda: National Cancer Institute;1959.
12. Greenwood M. The errors of sampling of the survivorship table, Vol. 33 of reports on public health and medical subjects. London: Her Majesty's Stationery Office;1926.
13. Brenner H, Arndt V. Recent increase in cancer survival according to age: higher survival in all age groups, but widening age gradient. Cancer Causes Control. 2004; 15:903–910. PMID: 15577292.
Article
14. Goodwin JS, Samet JM, Hunt WC. Determinants of survival in older cancer patients. J Natl Cancer Inst. 1996; 88:1031–1038. PMID: 8683633.
Article
15. Wedding U, Rohrig B, Klippstein A, Pientka L, Hoffken K. Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients. J Cancer Res Clin Oncol. 2007; 133:945–950. PMID: 17534661.
Article
16. Yancik R, Wesley MN, Ries LA, Havlik RJ, Long S, Edwards BK, et al. Comorbidity and age as predictors of risk for early mortality of male and female colon carcinoma patients: a population-based study. Cancer. 1998; 82:2123–2134. PMID: 9610691.
17. Quaglia A, Capocaccia R, Micheli A, Carrani E, Vercelli M. A wide difference in cancer survival between middle aged and elderly patients in Europe. Int J Cancer. 2007; 120:2196–2201. PMID: 17285582.
Article
18. Jeong O, Park YK. Clinicopathological features and surgical treatment of gastric cancer in South Korea: the results of 2009 nationwide survey on surgically treated gastric cancer patients. J Gastric Cancer. 2011; 11:69–77. PMID: 22076206.
Article
19. Verdecchia A, Mariotto A, Gatta G, Bustamante-Teixeira MT, Ajiki W. Comparison of stomach cancer incidence and survival in four continents. Eur J Cancer. 2003; 39:1603–1609. PMID: 12855268.
Article
20. Strong VE, Song KY, Park CH, Jacks LM, Gonen M, Shah M, et al. Comparison of gastric cancer survival following R0 resection in the United States and Korea using an internationally validated nomogram. Ann Surg. 2010; 251:640–646. PMID: 20224369.
Article
21. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Waldron W, et al. SEER cancer statistics review, 1975-2009. Bethesda: National Cancer Institute;2012.
22. Lin DW, Porter M, Montgomery B. Treatment and survival outcomes in young men diagnosed with prostate cancer: a Population-based Cohort Study. Cancer. 2009; 115:2863–2871. PMID: 19466697.
23. Kim Y, Jun JK, Choi KS, Lee HY, Park EC. Overview of the National Cancer screening programme and the cancer screening status in Korea. Asian Pac J Cancer Prev. 2011; 12:725–730. PMID: 21627372.
24. Yu GP, Ostroff JS, Zhang ZF, Tang J, Schantz SP. Smoking history and cancer patient survival: a hospital cancer registry study. Cancer Detect Prev. 1997; 21:497–509. PMID: 9398990.
25. Li N, Du XL, Reitzel LR, Xu L, Sturgis EM. Impact of enhanced detection on the increase in thyroid cancer incidence in the United States: review of incidence trends by socioeconomic status within the surveillance, epidemiology, and end results registry, 1980-2008. Thyroid. 2013; 23:103–110. PMID: 23043274.
Article
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