Clin Endosc.  2014 Sep;47(5):455-459. 10.5946/ce.2014.47.5.455.

Acute Ectopic Pancreatitis Occurring after Endoscopic Biopsy in a Gastric Ectopic Pancreas

  • 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
  • 2Department of Pathology, Pusan National University School of Medicine, Busan, Korea.


Ectopic pancreas is a congenital anomaly and the most common type of ectopic tissue in the gastrointestinal tract. Most patients with an ectopic pancreas are asymptomatic and rarely have complications. Ectopic pancreatitis after an endoscopic biopsy has not been reported. We report a patient who developed acute ectopic pancreatitis in the stomach after an endoscopic biopsy. A 71-year-old male patient presented with a subepithelial tumor (SET) in the stomach and had no symptoms. Endoscopic ultrasonography demonstrated a 30-mm hypoechoic mural mass, lobulated margins, and anechoic duct-like lesions. To obtain proper tissue specimen, endoscopic biopsy was performed through the opening on the surface of the mass. The pathologic results confirmed an ectopic pancreas. One day after the endoscopic biopsy, he developed persistent epigastric pain. His serum amylase and lipase elevated. Computed tomography of the abdomen showed swelling of the SET and diffuse edema of the gastric wall. His condition was diagnosed as acute ectopic pancreatitis occurring after endoscopic biopsy.


Pancreatitis; Ectopic pancreas; Stomach

MeSH Terms

Gastrointestinal Tract


  • Fig. 1 Endoscopic findings. (A) A subepithelial tumor with a nodular shape is found at the lesser curvature in the lower body of the stomach. (B) On close-up view, a small opening (arrow) is seen at the center. (C) On narrow-band imaging, the tumor is covered by normal gastric mucosa. (D) When the biopsy forceps is inserted into the opening, the forceps goes in deep. Therefore, it is possible to obtain the core tissue inside the tumor.

  • Fig. 2 (A, B) Endoscopic ultrasonography shows an about 30-mm heterogeneously hypoechoic mass in the third, fourth, and fifth layers. Its margins are lobulated and indistinct, and anechoic duct-like structures (arrow) are seen.

  • Fig. 3 Abdominal computed tomography (CT) findings. (A) On initial CT, a plaque-like mass (arrow) is seen at the posterior wall of the gastric lower body. (B) On CT during acute pain attack after the endoscopic biopsy, an enlargement of the subepithelial tumor (white arrow) and diffuse gastric wall edema are seen. The pancreas is normal (black arrow). When compared with the previous CT image, its density is more hypodense than that of the pancreas. These findings suggest the occurrence of acute ectopic pancreatitis.

  • Fig. 4 Pathological findings. (A) Irregularly arranged lobules of pancreatic acinar and dilated ducts are seen in the submucosa (H&E stain, ×40). (B) Acinar cells contain abundant granular eosinophilic cytoplasm in the apical aspect, with basal basophilic cytoplasm. Nuclei are basally located (H&E stain, ×400).


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