J Vet Sci.  2015 Jun;16(2):241-244. 10.4142/jvs.2015.16.2.241.

Intrapancreatic ectopic splenic tissue found in a cloned miniature pig

  • 1Laboratory Animal Research Center, Samsung Biomedical Research Institute, Suwon 440-746, Korea.
  • 2National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9410, USA.
  • 3Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. bclee@snu.ac.kr


Somatic cell nuclear transfer (SCNT) is a cost-effective technique for producing transgenic pigs. However, abnormalities in the cloned pigs might prevent use these animals for clinical applications or disease modeling. In the present study, we generated several cloned pigs. One of the pigs was found to have intrapancreatic ectopic splenic tissue during histopathology analysis although this animal was grossly normal and genetically identical to the other cloned pigs. Ectopic splenic tissue in the pancreas is very rare, especially in animals. To the best of our knowledge, this is the first such report for cloned pigs.


cloned pig; intrapancreatic ectopic splenic tissue; somatic cell nuclear transfer

MeSH Terms

Animals, Genetically Modified
Cloning, Organism
Nuclear Transfer Techniques/*veterinary
Splenic Diseases/pathology/*veterinary
Swine Diseases/*pathology
Swine, Miniature


  • Fig. 1 Ectopic splenic tissue in the pancreas of Clone 1. (A) The figure shows splenic tissue widely dispersed at the center of the section. (B) The boundary between the splenic tissue (right area) and pancreas (left area) was delineated by a fibrous capsule. H&E staining, 12.5× (A), 100× (B) magnification.


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