Ann Dermatol.  2002 Dec;14(4):220-225. 10.5021/ad.2002.14.4.220.

A Case of Glomeruloid Hemangioma in a Patient with Multicentric Castleman's Disease

Abstract

Glomeruloid hemangioma is a histologically distinctive cutaneous angioma which is rarely de-scribed in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome and multicentric Castleman's disease. We report an additional case of glomeruloid hemangioma in a 30-year-old Korean woman with multicentric Castleman's disease showing features of POEMS syndrome. Histopathology revealed multiple dermal dilated vascular spaces composed of a conglomerate of capillaries, resulting in structures reminiscent of renal glomeruli. Periodic acid-Schiff-positive and diastase-resistant eosinophilic globules were found within the cytoplasm of vacuolated endothelial cells. The endothelial cells lining the capillary loops showed positive immunostaining for factor VIII-related antigen and CD31.

Keyword

Glomeruloid hemangioma; Castleman's disease

MeSH Terms

Adult
Capillaries
Cytoplasm
Endothelial Cells
Eosinophils
Female
Giant Lymph Node Hyperplasia*
Hemangioma*
Humans
POEMS Syndrome
Skin
von Willebrand Factor
von Willebrand Factor

Cited by  1 articles

Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome
Jin Yong Lee, Jae Kyun Choi, Jae Won Ha, So Eun Park, Chul Woo Kim, Sang Seok Kim
Ann Dermatol. 2017;29(2):249-251.    doi: 10.5021/ad.2017.29.2.249.

Full Text Links
  • AD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr