Korean J Dermatol.  2006 Aug;44(8):976-979.

A Case of Kaposi's Sarcoma Associated with Castleman's Disease

Affiliations
  • 1Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea. crhaw@khmc.or.kr

Abstract

Castleman's disease, also known as angiofollicular lymphoid hyperplasia or giant lymph-node hyperplasia, is an unusual form of a lymphoproliferative disorder, and is divided clinically into a solitary and a multicentric form. The multicentric form of Castleman's disease is almost always of the plasma cell type. This can coexist with Kaposi's sarcoma in some cases. Kaposi's sarcoma is a multicentric, proliferative, vascular tumor involving cutaneous and visceral tissue. Iatrogenically-developed, immunosuppression-associated Kaposi's sarcoma is usually the result of immunosuppressive therapy. A 61-year-old man diagnosed as the plasma cell type of Castleman's disease, who had been treated with prednisolone for 2 years, was referred to the department of dermatology with numerous skin lesions consisting of confluent, violaceous-colored papules and plaques on his palm and soles. Histologic examination of the cutaneous lesions showed consistency with Kaposi's sarcoma. We report a rare case of Kaposi's sarcoma associated with multicentric Castleman's disease.

Keyword

Castleman's disease; Human herpesvirus 8; Kaposi's sarcoma

MeSH Terms

Dermatology
Giant Lymph Node Hyperplasia*
Herpesvirus 8, Human
Humans
Hyperplasia
Lymphoproliferative Disorders
Middle Aged
Plasma Cells
Prednisolone
Sarcoma, Kaposi*
Skin
Prednisolone
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